N'-[4-(methylamino)butyl]methanimidamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-[4-(methylamino)butyl]methanimidamide
• 化学式: C₆H₁₅N₃
• 分子量: 129.2
• InChiKey: XTGVYVCHFSBICZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] TARGETED IDURONATE-2-SULFATASE COMPOUNDS<br/>[FR] COMPOSÉS D'IDURONATE-2-SULFATASE CIBLÉS
  申请人：ANGIOCHEM INC

  公开号：WO2014082184A1

  公开（公告）日：2014-06-05

  The present invention is related to a compound that includes a lysosomal enzyme and a targeting moiety, for example, a compound that includes iduronate-2-sulfatase conjugated to Angiopep-2 through a linker formed by specific click chemistry reactions. In certain embodiments, these compounds, owing to the presence of the targeting moiety, can cross the blood-brain barrier or accumulate in the lysosome more effectively than the enzyme alone. The invention also features pharmaceutical compositions containing such compounds and methods for treating lysosomal storage disorders (e.g., mucopolysaccharidosis Type II) using such compounds.