N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;gadolinium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;gadolinium
• 化学式: C6H18GdN4
• 分子量: 303.5
• InChiKey: WQSOLJJQLLWSQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.92
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  76.1
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Conjugates of the B-subunit of shiga toxin for use as contrasting agents for imaging and therapy
  申请人：Institut Curie

  公开号：EP2740491A1

  公开（公告）日：2014-06-11

  Multivalent conjugates comprising the following formula: (STxB-linker A-S)x-GNS-(S-linker B-T)y wherein STxB is the B-subunit of Shiga toxin; linker A is a noncleavable linker; linker B is a cleavable linker used to release at least one T or a noncleavable linker; GNS is a gold nanostructure; S is a sulfhydryl group and x and y can vary from 1 to 8,000; and T is a molecule selected from the group of: contrast agents, cytotoxic agents, prodrugs and antigens and x and y can vary from 1 to 10,000. These multivalent conjugates can be used in therapy to treat cancer and in medical imaging. Methods to distinguish normal cells from abnormal cells and methods for treating cancer by photothermal therapy or photothermal therapy and cytotoxic therapy are also part of the present invention.

  包含以下公式的多价结合物：(STxB-连接剂A-S)x-GNS-(S-连接剂B-T)y，其中STxB是Shiga毒素的B亚单位；连接剂A是不可切割的连接剂；连接剂B是可切割的连接剂，用于释放至少一个T或不可切割的连接剂；GNS是金纳米结构；S是硫醇基团，x和y可以在1到8000之间变化；T是从对比剂、细胞毒性剂、前药和抗原组中选择的分子，x和y可以在1到10000之间变化。这些多价结合物可用于治疗癌症和医学成像。区分正常细胞和异常细胞的方法以及通过光热疗法或光热疗法和细胞毒疗法治疗癌症的方法也是本发明的一部分。
• [EN] CONJUGATES OF THE B-SUBUNIT OF SHIGA TOXIN FOR USE AS CONTRASTING AGENTS FOR IMAGING AND THERAPY<br/>[FR] CONJUGUÉS DE LA SOUS-UNITÉ B DE TOXINE DE SHIGA DESTINÉS À ÊTRE UTILISÉS COMME AGENTS DE CONTRASTE EN IMAGERIE ET EN THÉRAPIE
  申请人：INST CURIE

  公开号：WO2014086942A1

  公开（公告）日：2014-06-12

  Multivalent conjugates comprising the following formula: (STxB-linker A-S)x-GNS-(S-linker B-T)y wherein STxB is the B-subunit of Shiga toxin; linker A is a noncleavable linker; linker B is a cleavable linker used to release at least one T or a noncleavable linker; GNS is a gold nanostructure; S is a sulfhydryl group and x and y can vary from 1 to 8,000; and T is a molecule selected from the group of: contrast agents, cytotoxic agents, prodrugs and antigens and x and y can vary from 1 to 10,000. These multivalent conjugates can be used in therapy to treat cancer and in medical imaging. Methods to distinguish normal cells from abnormal cells and methods for treating cancer by photothermal therapy or photothermal therapy and cytotoxic therapy are also part of the present invention.

  包含以下公式的多价结合物：(STxB-连接剂A-S)x-GNS-(S-连接剂B-T)y，其中STxB是志贺毒素的B亚单位；连接剂A是不可切割的连接剂；连接剂B是可切割的连接剂，用于释放至少一个T或不可切割的连接剂；GNS是金纳米结构；S是硫醇基团，x和y的值可在1到8,000之间变化；T是从对比剂、细胞毒剂、前药和抗原组中选择的分子，x和y的值可在1到10,000之间变化。这些多价结合物可用于治疗癌症和医学成像。区分正常细胞和异常细胞的方法以及通过光热疗法或光热疗法和细胞毒疗法治疗癌症的方法也属于本发明的一部分。
• [EN] ENHANCED SENSITIVITY IN LIGAND BINDING ASSAYS PERFORMED WITH SECONDARY ION MASS SPECTROMETRY<br/>[FR] MEILLEURE SENSIBILITÉ DANS DES DOSAGES DE LIAISON DE LIGAND RÉALISÉS PAR SPECTROMÉTRIE DE MASSE D'IONS SECONDAIRES
  申请人：BIOSIMS TECH

  公开号：WO2016174525A1

  公开（公告）日：2016-11-03

  The present invention relates to a method for quantitating a target molecule in at least one assay sample comprising: depositing on a biochip at least one first capture molecule; adding at least one target molecule and allowing the target molecule to react with said at least one first capture molecule; adding at least one second capture molecule that reacts with the target molecule, this at least one second capture molecule being attached to at least one nanoparticle or microparticle wherein specific ionizable atoms are part of the at least one nanoparticle or microparticle or at least one second capture molecule being attached to at least one nanoparticle or microparticle comprising specific ionizable atoms being attached at their surface or to said at least one nanoparticle or microparticle having specific ionizable atoms being part of a molecule attached to the at least one nanoparticle or microparticle at their surface or at least one second capture molecule having specific ionizable atoms attached thereto wherein said at least one second capture molecule is attached to nanoparticles or microparticles or specific ionizable atoms that are attached to at least one second capture molecule and specific ionizable atoms that are also attached to the microparticles and nanoparticles at their surface; and scanning the biochip by secondary ion mass spectrometry to measure the secondary ions that are emitted by the specific ionizable atoms. Kits comprising the nanoparticles or microparticles and methods of using the nanoparticles or microparticles are also described.