(2Z)-2-[8-[[7-chloro-2-(cyclobutadienyl)imidazo[4,5-b]pyridin-3-yl]methyl]-3-fluoro-6H-benzo[c][1]benzoxepin-11-ylidene]propanenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噁庚英
• 英文名称: (2Z)-2-[8-[[7-chloro-2-(cyclobutadienyl)imidazo[4,5-b]pyridin-3-yl]methyl]-3-fluoro-6H-benzo[c][1]benzoxepin-11-ylidene]propanenitrile
• 化学式: C₂₈H₁₈ClFN₄O
• 分子量: 480.9
• InChiKey: ZDDTVQNMTNYDJW-XYGWBWBKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  35
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• DIBENZOOXEPIN DERIVATIVE
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP2740730B1

  公开（公告）日：2016-11-16
• ANALOGUES OF CILOSTAZOL
  申请人：CONCERT PHARMACEUTICALS INC.

  公开号：US20130131021A1

  公开（公告）日：2013-05-23

  This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of a phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.
• US8969345B2
  申请人：——

  公开号：US8969345B2

  公开（公告）日：2015-03-03