4-[(4S)-4-methyl-1,1-dioxo-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-[(4S)-4-methyl-1,1-dioxo-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile
• 化学式: C₁₄H₁₄N₄O₂S
• 分子量: 302.35
• InChiKey: TZOOSWLWLWLZNF-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  94.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS
  申请人：Pfizer Inc.

  公开号：EP2925725A1

  公开（公告）日：2015-10-07
• [EN] NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS<br/>[FR] NOUVEAUX MODULATEURS ANDROGÉNIQUES SÉLECTIFS
  申请人：PFIZER

  公开号：WO2014087298A1

  公开（公告）日：2014-06-12

  The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or –CR0 --, where R0 is hydrogen, C1 -C6 linear or branched chain alkyl, etc., Z is –CRe --, or, –N--, where Re is hydrogen, C1 -C6 linear or branched chain alkyl,etc.; R1 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1 -C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1 -C6 linear or branched chain alkyl, etc.;. R5 and R6 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1 -C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1 -C6 linear or branched chain alkyl, etc.; Q is --CO--, --(CH2 )q --, --(CHRS )q --, or –(CRS Rt )q--, where RS and Rt are independently C1 -C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.