Compositions for the treatment of cancer comprising coumarin and thiocoumarin derivatives of Formulas I- XII are disclosed. Said derivatives preferentially inhibit carbonic anhydrase IX and XII (which are associated with hypoxic and metastatic tumours) over inhibiting carbonic anhydrase I and II activity. The compositions therefore are suited for treatment of hypoxic or metastatic cancers due to this selective mechanism of action.
本发明揭示了用于治疗癌症的组合物,包括公开的具有I-XII式的
香豆素和
硫代
香豆素衍
生物。所述衍
生物优先抑制与低氧和转移性肿瘤相关的
碳酸酐酶IX和XII,而不是抑制
碳酸酐酶I和II的活性。因此,这些组合物由于这种选择性作用机制而适用于治疗低氧或转移性癌症。