(5Z)-5-[(2,4-dihydroxyphenyl)methylidene]-2-phenylimino-1,3-thiazolidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (5Z)-5-[(2,4-dihydroxyphenyl)methylidene]-2-phenylimino-1,3-thiazolidin-4-one
• 化学式: C₁₆H₁₂N₂O₃S
• 分子量: 312.3
• InChiKey: RZHCPZWKVYZHDR-ZSOIEALJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] THIAZOLONE COMPOUNDS FOR TREATMENT OF CANCER<br/>[FR] COMPOSES DE THIAZOLONE PERMETTANT DE TRAITER LE CANCER
  申请人：UNIV TEXAS

  公开号：WO2005082363A1

  公开（公告）日：2005-09-09

  The present invention provides concerns a thiazolone compound 5-[(4­ methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone or an analog thereof for the treatment of cancers. This compound induces apoptosis in cancer cells without killing of normal healthy cells. In addition, 5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone or an analog thereof is able to overcome multidrug resistance in cancer cells. Thus, the present invention provides a thiazolone compound 5-[(4-methylphenyl)methylene]-2-(phenylamino)­ 4(5H)-thiazolone or an analog thereof as a therapeutic agent for treating cancers.