2-morpholino-2-(thiazol-5-yl)acetonitrile

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-morpholino-2-(thiazol-5-yl)acetonitrile
• 英文别名: 2-Morpholin-4-yl-2-(1,3-thiazol-5-yl)acetonitrile；2-morpholin-4-yl-2-(1,3-thiazol-5-yl)acetonitrile
• 化学式: C₉H₁₁N₃OS
• 分子量: 209.272
• InChiKey: FEAXILSZKGDXSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  77.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONIST
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：US20150322008A1

  公开（公告）日：2015-11-12

  The invention relates to indole carboxamide derivatives of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  本发明涉及公式（I）中的吲哚羧酰胺衍生物，其中R1、R2、R3、R4、R5和R6如描述中所定义，其制备和用作药学活性化合物。
• Substituted thiazole or oxazole as P2X7 receptor antagonists
  申请人：AXXAM S.p.A.

  公开号：EP2905282A1

  公开（公告）日：2015-08-12

  The present invention is related to novel substituted thiazoles and oxazoles compounds of the following formula (I) having P2X7 receptor (P2X7) antagonistic properties: The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity.

  本发明涉及具有 P2X7 受体（P2X7）拮抗特性的下式（I）的新型取代噻唑和噁唑化合物： 这些化合物可用于治疗或预防与 P2X7 受体活性相关的疾病。
• Substituted thiazole or oxazole P2X7 receptor antagonists
  申请人：Axxam S.P.A.

  公开号：US10167281B2

  公开（公告）日：2019-01-01

  The present invention refers to novel substituted thiazole and oxazole compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties: The compounds are useful in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.

  本发明涉及具有 P2X7 受体（P2X7）拮抗特性的新型取代的式 (I) 噻唑和噁唑化合物： 这些化合物可用于治疗或预防动物，特别是人类与 P2X7 受体活性相关的疾病。
• INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2931717B1

  公开（公告）日：2016-12-07
• SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS
  申请人：AXXAM S.p.A.

  公开号：EP3102573B1

  公开（公告）日：2018-04-11