2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;pentan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;pentan-1-amine
• 英文别名: 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;pentan-1-amine
• 化学式: C25H35N9O5
• 分子量: 541.6
• InChiKey: IKYAGKWERVQSBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  237
• 氢给体数：
  6
• 氢受体数：
  13

文献信息

• [EN] COMPOSITIONS AND METHODS FOR CAPTURE OF CELLULAR TARGETS OF BIOACTIVE AGENTS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE CAPTURE DE CIBLES CELLULAIRES D'AGENTS BIOACTIFS
  申请人：PROMEGA CORP

  公开号：WO2014093671A1

  公开（公告）日：2014-06-19

  The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.

  本发明提供了一种用于捕获和识别生物活性剂的细胞靶标的组合物和方法。具体来说，本文提供了与捕获配体、细胞靶标（可选择性地标记有报告物）、捕获蛋白（可选择性地作为捕获融合物存在）、表面（例如，显示捕获配体、捕获蛋白或捕获融合物）以及用于捕获和识别生物活性剂的细胞靶标的方法。
• COMPOSITIONS AND METHODS FOR CAPTURE OF CELLULAR TARGETS OF BIOACTIVE AGENTS
  申请人：Promega Corporation

  公开号：EP2931305B1

  公开（公告）日：2018-11-28
• SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES
  申请人：Promega Corporation

  公开号：EP2969435A1

  公开（公告）日：2016-01-20
• [EN] SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES<br/>[FR] SUBSTRATS POUR LA FIXATION COVALENTE DE PROTÉINES À DES GROUPES FONCTIONNELS OU DES SURFACES SOLIDES
  申请人：PROMEGA CORP

  公开号：WO2014151282A1

  公开（公告）日：2014-09-25

  The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.