4-(Diazepan-1-ylsulfonyl)isoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-(Diazepan-1-ylsulfonyl)isoquinoline
• 英文别名: 4-(diazepan-1-ylsulfonyl)isoquinoline
• 化学式: C₁₄H₁₇N₃O₂S
• 分子量: 291.37
• InChiKey: ODCDHDWZIQWKIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  70.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] IMMUNOGENIC COMPOSITIONS PREPARED FROM TUMOR CELLS DERIVED FROM PERIPHERAL BLOOD AND ORIGINATING FROM A SOLID TUMOR AND THEIR USE<br/>[FR] COMPOSITIONS IMMUNOGÈNES PRÉPARÉES À PARTIR DE CELLULES TUMORALES DÉRIVÉES DU SANG PÉRIPHÉRIQUE ET PROVENANT D'UNE TUMEUR SOLIDE ET LEUR UTILISATION
  申请人：NEOSTEM ONCOLOGY LLC

  公开号：WO2016081554A1

  公开（公告）日：2016-05-26

  The described invention provides an immunopotent tumor-specific cancer cell product containing an immunogenic composition containing an immunostimulatory amount of an isolated population of dendritic cells contacted ex vivo with a cancer- specific cancer stem cell derived from a tumor cell, a tumor cell cluster, a tumor cell aggregate or a combination thereof expressing at least one cancer-specific antigen, the tumor cell, tumor cell cluster, tumor cell aggregate or the combination thereof being derived from peripheral blood; and an adjuvant; and a pharmaceutically acceptable carrier; as well as methods for preparing and using same.