N-[[4-(methylaminomethyl)cyclohexyl]methyl]ethanamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[[4-(methylaminomethyl)cyclohexyl]methyl]ethanamine
• 化学式: C₁₁H₂₄N₂
• 分子量: 184.32
• InChiKey: DARNKLQKUQOANP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] DOSAGES OF IMMUNOCONJUGATES OF ANTIBODIES AND SN-38 FOR IMPROVED EFFICACY AND DECREASED TOXICITY<br/>[FR] DOSAGES D'IMMUNO-CONJUGUÉS D'ANTICORPS ET DE SN-38 POUR AMÉLIORER L'EFFICACITÉ ET RÉDUIRE LA TOXICITÉ
  申请人：IMMUNOMEDICS INC

  公开号：WO2014092804A1

  公开（公告）日：2014-06-19

  The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to EGP-1 (TROP-2), CEACAM5, CEACAM6, CD74, CD19, CD20, CD22, CSAp, HLA-DR, AFP or MUCSac and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 24 mg/kg, preferably 4, 6, 8, 9, 10, 12, 16 or 18 mg/kg. When administered at specified dosages and schedules, the immunoconjugate can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy.