N,N'-bis(4-ethylphenyl)-2,2-bis(ethylsulfonyl)ethene-1,1-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-bis(4-ethylphenyl)-2,2-bis(ethylsulfonyl)ethene-1,1-diamine
• 英文别名: 1-N,1-N'-bis(4-ethylphenyl)-2,2-bis(ethylsulfonyl)ethene-1,1-diamine
• 化学式: C₂₂H₃₀N₂O₄S₂
• mdl: MFCD00346397
• 分子量: 450.623
• InChiKey: JIABWPFIQBTSFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,1,2,2-四(乙基磺酰基)乙烯 、 4-乙基苯胺 以56%的产率得到
  参考文献：
  名称：

  PETUXOVA, N. P.;DONTSOVA, N. E.;PRILEZHAEVA, E. N.;BOGDANOV, V. S., IZV. AN CCCP. CEP. XIM., 1984, N 3, 611-617

  摘要：

  DOI：

文献信息

• Polysulfonylethenes. Communication 3. Reactions of tetrakis(alkylsulfonyl) ethenes with amines
  作者：N. P. Petukhova、N. E. Kontsova、E. N. Prilezhaeva、V. S. Bogdanov

  DOI：10.1007/bf00995697

  日期：1984.3
• Castration-Resistant Prostate Cancer
  申请人：NUtech Ventures

  公开号：US20160310528A1

  公开（公告）日：2016-10-27

  This invention relates to inhibitors of UDP-glucose dehydrogenase, and more particularly to UDP-glucose dehydrogenase inhibitors that are useful in the treatment of prostate cancer. Methods of inhibiting UDP-glucose dehydrogenase and improving the efficacy of additional prostate cancer therapies are also provided.
• [EN] CASTRATION-RESISTANT PROSTATE CANCER<br/>[FR] CANCER DE LA PROSTATE RÉSISTANT À LA CASTRATION
  申请人：NUTECH VENTURES

  公开号：WO2016172545A1

  公开（公告）日：2016-10-27

  This invention relates to inhibitors of UDP-glucose dehydrogenase, and more particularly to UDP-glucose dehydrogenase inhibitors that are useful in the treatment of prostate cancer. Methods of inhibiting UDP-glucose dehydrogenase and improving the efficacy of additional prostate cancer therapies are also provided.