N’-(2-hydroxybenzylidene)-3,4,5-trihydroxybenzoylhydrazone | 25054-55-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N’-(2-hydroxybenzylidene)-3,4,5-trihydroxybenzoylhydrazone
• 英文别名: 3,4,5-triphenolbenzoylsalicylaldehyde hydrazone；3,4,5-trihydroxy-N-[(2-hydroxyphenyl)methylideneamino]benzamide
• CAS: 25054-55-1
• 化学式: C₁₄H₁₂N₂O₅
• 分子量: 288.26
• InChiKey: KEAZGRGPTHWCQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  122
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  gadolinium(III) acetate tetrahydrate 、 N’-(2-hydroxybenzylidene)-3,4,5-trihydroxybenzoylhydrazone 以 乙醇 为溶剂， 以76%的产率得到
  参考文献：
  名称：

  Synthesis and Characterization of 3, 4, 5-triphenolbenzoylsalicylaldehyde Hydrazone and its Rare Earth Metal Complexes with Antitumor Activities

  摘要：

  A new gallic acid derivative, 3, 4, 5-triphenolbenzoylsalicylaldehyde hydrazone (HL), and its four rare earth metal complexes, [LnL (OAc)2] H2O (Ln = La3 +, Sm3 +, Tb3 +, Dy3 +), have been synthesized and characterized on the basis of elemental analyses, molar conductivity, IR and 1H NMR spectra. The antitumor activities against HL-60 and A - 549 cell lines of the prepared compounds have also been evaluated. The results indicate that the antitumor activity against the human leukemia cell lineHL-60 than the ligand HL, and the antitumor activity of the ligand is largely changed by the formation of the complexes.

  DOI：

  10.1080/15533170802525795

文献信息

• COMPOUNDS, COMPOSITIONS AND TREATMENTS FOR V-ATPase RELATED DISEASES
  申请人：Kartner Norbert

  公开号：US20110189306A1

  公开（公告）日：2011-08-04

  The present invention relates to therapeutic and/or prophylactic uses of hydrazide compounds and to pharmaceutical compositions containing one or more of these compounds as an active component for treating a disease or disorder requiring modulation of vacuolar (H+)-ATPases.