5-甲基-5,6,7,8-四氢-吡啶并[3,4-b]吡嗪 | 757942-36-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 5-甲基-5,6,7,8-四氢-吡啶并[3,4-b]吡嗪
• 英文名称: 5-Methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine
• CAS: 757942-36-2
• 化学式: C₈H₁₁N₃
• 分子量: 149.19
• InChiKey: NREAXSXHEQIWTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• US7388019B2
  申请人：——

  公开号：US7388019B2

  公开（公告）日：2008-06-17
• [EN] 3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES<br/>[FR] DERIVES D'ACIDE 3-AMINO-4-PHENYLBUTANOIQUE UTILISES COMME INHIBITEURS DE DIPEPTIDYLE PEPTIDASE POUR LE TRAITEMENT OU LA PREVENTION DU DIABETE
  申请人：MERCK & CO INC

  公开号：WO2004069162A2

  公开（公告）日：2004-08-19

  The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
• [EN] WNT SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF<br/>[FR] INHIBITEURS DE LA VOIE DE SIGNALISATION WNT ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：ZHANG XIAOHU

  公开号：WO2017062688A1

  公开（公告）日：2017-04-13

  Inhibitors of Wnt signaling pathway with structures of Formula I are disclosed, together with their pharmaceutical salts. Applications of compounds of Formula I in inhibiting or modulating the Wnt signaling pathway are also disclosed. Compounds of Formula I can treat disorders caused by aberrant activation of the Wnt signaling pathway.