3-[2-(3-Aminopropyl)-5,8-difluoro-4-oxoquinazolin-3-yl]benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[2-(3-Aminopropyl)-5,8-difluoro-4-oxoquinazolin-3-yl]benzonitrile
• 英文别名: 3-[2-(3-aminopropyl)-5,8-difluoro-4-oxoquinazolin-3-yl]benzonitrile
• 化学式: C₁₈H₁₄F₂N₄O
• 分子量: 340.3
• InChiKey: YDNDESQAWUGIHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  82.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
  申请人：Gilead Calistoga LLC

  公开号：EP2935246A1

  公开（公告）日：2015-10-28
• [EN] ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS<br/>[FR] INHIBITEURS D'ISOQUINOLINONE PHOSPHATIDYLINOSITOL 3-KINASE OU DE QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE
  申请人：GILEAD CALISTOGA LLC

  公开号：WO2014100767A1

  公开（公告）日：2014-06-26

  The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), or pharmaceutically acceptable salts thereof, in which n, m, R1, R2, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more P13K isoforms, such as PI3K8. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3Kδ.