2-[2-[[6-Amino-5-[2-(5-fluoropyridin-2-yl)ethynyl]pyrimidin-4-yl]amino]ethyl]-8-chloro-3-phenylquinazolin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[2-[[6-Amino-5-[2-(5-fluoropyridin-2-yl)ethynyl]pyrimidin-4-yl]amino]ethyl]-8-chloro-3-phenylquinazolin-4-one
• 英文别名: 2-[2-[[6-amino-5-[2-(5-fluoropyridin-2-yl)ethynyl]pyrimidin-4-yl]amino]ethyl]-8-chloro-3-phenylquinazolin-4-one
• 化学式: C₂₇H₁₉ClFN₇O
• 分子量: 511.9
• InChiKey: GBLIELRPNULVET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• SUBSTITUTED PYRIMIDINE AMINOALKYL-QUINAZOLONES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
  申请人：Gilead Calistoga LLC

  公开号：EP2941426A1

  公开（公告）日：2015-11-11
• [EN] SUBSTITUTED PYRIMIDINE AMINOALKYL-QUINAZOLONES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS<br/>[FR] PYRIMIDINE AMINOALKYL-QUINAZOLONES SUBSTITUÉES EN TANT QU'INHIBITEURS DE PHOSPHATIDYLINOSITOL 3-KINASE
  申请人：GILEAD CALISTOGA LLC

  公开号：WO2014100765A1

  公开（公告）日：2014-06-26

  The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts thereof, in which R1, R2, n, R3, R4, R5 and R6 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3Kδ. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3Kδ.