2,4-Diamino-6-[1-[5-chloro-3-[3-(difluoromethyl)-5-methylphenyl]-6-fluoro-4-oxoquinazolin-2-yl]ethylamino]pyrimidine-5-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,4-Diamino-6-[1-[5-chloro-3-[3-(difluoromethyl)-5-methylphenyl]-6-fluoro-4-oxoquinazolin-2-yl]ethylamino]pyrimidine-5-carbonitrile
• 英文别名: 2,4-diamino-6-[1-[5-chloro-3-[3-(difluoromethyl)-5-methylphenyl]-6-fluoro-4-oxoquinazolin-2-yl]ethylamino]pyrimidine-5-carbonitrile
• 化学式: C₂₃H₁₈ClF₃N₈O
• 分子量: 514.9
• InChiKey: KFBQONXVSQCTAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• HETEROLEPTIC IRIDIUM COMPLEXES AS DOPANTS
  申请人：Universal Display Corporation

  公开号：US20140159028A1

  公开（公告）日：2014-06-12

  Novel phosphorescent heteroleptic iridium complexes with phenylpyridine and dibenzo-containing ligands are provided. Alkyl substitution at specific positions on the ligands gives rise to compounds with improved OLED properties, including saturated green emission.

  提供了含有苯基吡啶和二苯基配体的新型磷光杂环铱配合物。在配体的特定位置进行烷基取代可产生具有改善OLED性能的化合物，包括饱和绿色发射。
• [EN] ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS<br/>[FR] INHIBITEURS D'ISOQUINOLINONE PHOSPHATIDYLINOSITOL 3-KINASE OU DE QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE
  申请人：GILEAD CALISTOGA LLC

  公开号：WO2014100767A1

  公开（公告）日：2014-06-26

  The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), or pharmaceutically acceptable salts thereof, in which n, m, R1, R2, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more P13K isoforms, such as PI3K8. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3Kδ.