N-ethyl-N'-[[2-[[3-(ethylamino)propylamino]methyl]cyclopentyl]methyl]propane-1,3-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethyl-N'-[[2-[[3-(ethylamino)propylamino]methyl]cyclopentyl]methyl]propane-1,3-diamine
• 化学式: C₁₇H₃₈N₄
• 分子量: 298.5
• InChiKey: RDSWWEGNLFJJHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  48.1
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Thienopyranones as Kinase Inhibitors
  申请人：Morales Guillermo A.

  公开号：US20140073584A1

  公开（公告）日：2014-03-13

  The invention relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their use in manufactures and methods for modulating biological processes including inhibition of kinase activity such as PI-3 kinase.

  本发明涉及公式I（或其药学上可接受的盐）的化合物，其定义如下，以及其制药组合物，以及它们在制造和调节生物过程的方法中的应用，包括抑制激酶活性，如PI-3激酶。
• Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
  申请人：Pathologica LLC

  公开号：US10292950B2

  公开（公告）日：2019-05-21

  Disclosed herein are compounds, pharmaceutical compositions, and methods for the treatment of diseases such as inflammation and/or pain, comprising the administration of a therapeutically effective amount of a non-steroidal, non-opioid compound having GI-/renal-/platelet-sparing activities, and wide safety margins with no appreciable inhibition of either form of cyclooxygenase.

  本文公开了用于治疗炎症和/或疼痛等疾病的化合物、药物组合物和方法，其中包括施用治疗有效量的非类固醇、非阿片类化合物，该化合物具有胃肠道/肾脏/血小板疏松活性和较宽的安全边际，对两种形式的环氧化酶均无明显抑制作用。
• Method of Treatment with Anti-Inflammatory and Analgesic Compounds Which are GI-, Renal-, and Platelet-Sparing
  申请人：McKearn John

  公开号：US20140187643A1

  公开（公告）日：2014-07-03

  Disclosed herein are compounds, pharmaceutical compositions, and methods for the treatment of diseases such as inflammation and/or pain, comprising the administration of a therapeutically effective amount of a non-steroidal, non-opioid compound having GI-/renal-/platelet-sparing activities, and wide safety margins with no appreciable inhibition of either form of cyclooxygenase.
• METHOD OF TREATMENT WITH ANTI-INFLAMMATORY AND ANALGESIC COMPOUNDS WHICH ARE GI-, RENAL-, AND PLATELET-SPARING
  申请人：Pathologica LLC

  公开号：US20180369170A1

  公开（公告）日：2018-12-27

  Disclosed herein are compounds, pharmaceutical compositions, and methods for the treatment of diseases such as inflammation and/or pain, comprising the administration of a therapeutically effective amount of a non-steroidal, non-opioid compound having GI-/renal-/platelet-sparing activities, and wide safety margins with no appreciable inhibition of either form of cyclooxygenase.
• US9675566B2
  申请人：——

  公开号：US9675566B2

  公开（公告）日：2017-06-13