2-(4-oxoquinazolin-3-yl)-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(4-oxoquinazolin-3-yl)-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
• 化学式: C₁₉H₁₅N₅O₄S₂
• 分子量: 441.5
• InChiKey: GBPQUXCIPVPEOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  157
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Antiviral Drugs for Treatment or Prevention of Dengue Infection
  申请人：Byrd Chelsea M.

  公开号：US20100189685A1

  公开（公告）日：2010-07-29

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR
  申请人：RYDER Sean

  公开号：US20110065704A1

  公开（公告）日：2011-03-17

  The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
• Antiviral Drugs for Treatement or Prevention of Dengue Infection
  申请人：Siga Technologies Inc.

  公开号：US20130303491A1

  公开（公告）日：2013-11-14

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• ANTIVIRAL DRUGS FOR TREATMENT OR PREVENTION OF DENGUE INFECTION
  申请人：Siga Technologies, Inc.

  公开号：US20160250233A1

  公开（公告）日：2016-09-01

  Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
• US8377639B2
  申请人：——

  公开号：US8377639B2

  公开（公告）日：2013-02-19