(1R,2S,5S,8S,9R,17R,18R,21S,24R,26R,27S)-5-hydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacosa-11,14-diene-4,10,22,29-tetrone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (1R,2S,5S,8S,9R,17R,18R,21S,24R,26R,27S)-5-hydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacosa-11,14-diene-4,10,22,29-tetrone
• 化学式: C₂₈H₃₀O₉
• 分子量: 510.5
• InChiKey: HVTFEHJSUSPQBK-QOTOJMEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  37
• 可旋转键数：
  0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• COMPOSITIONS, METHODS AND KITS USING FOR INDUCING OR ENHANCING NEUROGENESIS IN CELLS AND TISSUE
  申请人：Biocrescentia, LLC

  公开号：US20140187618A1

  公开（公告）日：2014-07-03

  Compositions, methods, and kits including extracts containing physalins and pure physalins are provided for inducing neurogenesis in cells and tissues. The extracts for example are obtained from natural sources such as a plant, for example Physalis angulata . The extracts and purified physalins increase proliferation of neural stem cells, differentiation of the neural progenitor cells in areas of the brain, for example the hippocampus, and are effective for treating neurodegenerative disorders, neurological disease, and neurological conditions.