(1S,8R)-8-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-4-ethyl-7-oxo-2-thiabicyclo[4.2.0]oct-4-ene-5-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫吡喃类
• 英文名称: (1S,8R)-8-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-4-ethyl-7-oxo-2-thiabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
• 化学式: C₁₈H₂₁N₅O₇S₂
• 分子量: 483.5
• InChiKey: FNNWTRZTFONSMV-LYLCMGFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  248
• 氢给体数：
  4
• 氢受体数：
  13

文献信息

• Solid Forms of Ceftolozane
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20160228448A1

  公开（公告）日：2016-08-11

  Ceftolozane Sulfate is a cephalosporin antibacterial agent. Novel, stable, solid forms of the pharmaceutically acceptable sulfate salt of ceftolozane have been isolated via lyophilization. Characterization and identification of these solid forms by XRPD and Raman IR, as well as methods for their preparation and use in pharmaceutical compositions, are described.

  头孢氨苄磺酸盐是一种头孢菌素类抗菌剂。通过冷冻干燥法，分离出了药用可接受的头孢洛杉磺酸盐的新型、稳定、固态形式。本文描述了通过XRPD和Raman IR对这些固态形式的表征和鉴定，以及它们在制药组成物中的制备和使用方法。
• TAZOBACTAM ARGININE ANTIBIOTIC COMPOSITIONS
  申请人：Cubist Pharmaceuticals, Inc.

  公开号：US20140187528A1

  公开（公告）日：2014-07-03

  This disclosure provides compositions comprising a beta-lactam compound and crystalline tazobactam arginine, and related methods and uses of these compositions.
• SOLID FORMS OF CEFTOLOZANE AND PROCESSES FOR PREPARING
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20220056045A1

  公开（公告）日：2022-02-24

  The instant invention is related to a novel solid form of ceftolozane sulfate (the DMAc solvate of ceftolozane sulfate (Form 3)), compositions comprising ceftolozane sulfate DMAc solvate (Form 3), synthesis of Form 3 and an improved crystallization process using Form 3 to prepare ceftolozane sulfate Form 2. Novel compositions also include ceftolozane sulfate solid Form 3 and/or other crystalline and amorphous solid forms of ceftolozane.