1-Dodecanamine, N-propyl- | 45185-60-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Dodecanamine, N-propyl-
• 英文别名: N-propyldodecan-1-amine
• CAS: 45185-60-2
• 化学式: C₁₅H₃₃N
• 分子量: 227.43
• InChiKey: CEKFCJBSYYWXGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Dodecanamine, N-propyl- 、 溴代十二烷 生成 Didodecyl-propyl-amine
  参考文献：
  名称：

  SCHADE, W.;BEGER, J.;JACOBI, R.;NEUMANN, R., J. PRAKT. CHEM., 1983, 325, N 3, 364-374

  摘要：

  DOI：

文献信息

• [EN] INHIBITORS OF NHE-MEDIATED ANTIPORT<br/>[FR] INHIBITEURS D'ANTIPORT À MÉDIATION PAR NHE
  申请人：ARDELYX INC

  公开号：WO2018129557A1

  公开（公告）日：2018-07-12

  The present disclosure is directed to compounds (Ι') and to their use in methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds (Ι') and their use in methods for the treatment of hypertension. The present disclosure is also directed to compounds (Ι') and to their use in methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

  本公开涉及化合物(Ι')及其在治疗与液体潴留或盐超负荷相关的疾病的方法中的用途，例如心力衰竭（尤其是充血性心力衰竭）、慢性肾病、终末期肾病、肝病以及过氧化物酶体增殖物激活受体（PPAR）gamma激动剂引起的液体潴留。本公开还涉及化合物(Ι')及其在治疗高血压的方法中的用途。本公开还涉及化合物(Ι')及其在治疗胃肠道疾病的方法中的用途，包括治疗或减少与胃肠道疾病相关的疼痛。
• [EN] COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR L'ADMINISTRATION INTRACELLULAIRE D'AGENTS THÉRAPEUTIQUES ET/OU PROPHYLACTIQUES
  申请人：MODERNATX INC

  公开号：WO2017112865A1

  公开（公告）日：2017-06-29

  The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

  该披露涉及氨基脂质和相关组合物。纳米粒子组合物包括氨基脂质以及额外的脂质，如磷脂、结构脂质、PEG脂质或二者的组合。纳米粒子组合物还包括治疗和/或预防剂，如RNA，可用于将治疗和/或预防剂传递至哺乳动物细胞或器官，例如，调节多肽、蛋白质或基因表达。
• USE OF AMIDES AND/OR POLYAMIDES AS AUXILIARY AGENTS FOR ASPHALT AND BITUMEN COMPOSITIONS
  申请人：Bigorra Llosas Joaquin

  公开号：US20110118391A1

  公开（公告）日：2011-05-19

  Suggested is the use of amides and/or polyamides obtainable by condensation of (a) mono- and/or dicarboxylic acids and (b) amines and/or polyamines as auxiliary agents for aqueous asphalt and bitumen compositions.

  建议使用通过（a）一元和/或二元羧酸与（b）胺和/或多胺缩合得到的酰胺和/或聚酰胺作为水性沥青和沥青组合物的助剂。
• [EN] CYCLOHEXENE DERIVATIVES AS FRAGRANCES AND/OR FLAVORS<br/>[FR] DÉRIVÉS DE CYCLOHEXÈNE COMME FRAGRANCES ET/OU ARÔMES
  申请人：SYMRISE AG

  公开号：WO2017133754A1

  公开（公告）日：2017-08-10

  The present invention relates to novel cyclohexene derivatives selected from the group consisting of formula (la) and/or (lb), and the use of the cyclohexene derivatives and their isomers as fragrances, especially as fragrances with a rhubarb odour tonality, and fragrance and/or flavouring compositions as well as consumer products, comprising the cyclohexene derivatives of formula (la) and/or (lb).

  本发明涉及从化学式（Ia）和/或（Ib）所述的新型环己烯衍生物中选择的环己烯衍生物，以及将环己烯衍生物及其异构体用作香料，特别是具有大黄气味音调的香料，以及包含化学式（Ia）和/或（Ib）所述的环己烯衍生物的香料和/或调味剂组合物以及消费产品。
• Cationic Amino Acid Type Lipid
  申请人：Takeoka Shinji

  公开号：US20090012306A1

  公开（公告）日：2009-01-08

  The present invention provides a novel complex lipid having a cationic functional group derived from an amino acid. Namely, the present invention provides a cationic acid amino acid type lipid represented by the following formula: wherein, R 1 is a hydrocarbon group having a cationic functional group derived from an amino acid, R 2 and R 3 are each independently a chain hydrocarbon group, A 1 and A 2 are each independently a linkage group selected from the group consisting of —COO—, —OCO—, —CONH— and NHCO—, and n is an integer of 2 to 4.

  本发明提供一种新型的复合脂质，其具有源自氨基酸的阳离子功能基团。即，本发明提供一种由以下式表示的阳离子酸氨基酸型脂质：其中，R1是具有源自氨基酸的阳离子功能基团的烃基，R2和R3各自独立地是链烃基，A1和A2各自独立地是从羧基团、酰基团、酰胺基团和酰胺酰基团中选取的连接基团，n是2至4之间的整数。