(3-Methoxy-1-phosphonopropyl)-dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (3-Methoxy-1-phosphonopropyl)-dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium
• 英文别名: (3-methoxy-1-phosphonopropyl)-dimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium
• 化学式: C12H25NO6P+
• 分子量: 310.3
• InChiKey: RHWKGXPNXRBEQT-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Surface modification method and surface-modified elastic body
  申请人：SUMITOMO RUBBER INDUSTRIES, LTD.

  公开号：EP2752436A1

  公开（公告）日：2014-07-09

  The present invention aims to provide a method for surface-modifying a rubber vulcanizate or a thermoplastic elastomer, which is capable of cost-effectively imparting a variety of functions, such as sliding properties and biocompatibility, according to the applications. The present invention relates to a surface modification method for surface-modifying an object of a rubber vulcanizate or a thermoplastic elastomer, the method including: step 1 of forming polymerization initiation points A on a surface of the object; step 2 of radically polymerizing a non-functional monomer, starting from the polymerization initiation points A, to grow non-functional polymer chains; step 3 of forming polymerization initiation points B on the surface of the object where the non-functional polymer chains are formed; and step 4 of radically polymerizing a functional monomer, starting from the polymerization initiation points B, to grow functional polymer chains.

  本发明旨在提供一种对橡胶硫化弹性体或热塑性弹性体进行表面改性的方法，该方法能够根据应用情况，经济有效地赋予橡胶硫化弹性体或热塑性弹性体多种功能，如滑动性能和生物相容性。本发明涉及一种表面改性方法，用于对橡胶硫化胶或热塑性弹性体的物体进行表面改性，该方法包括：步骤 1：在物体表面形成聚合起始点 A；步骤 2：从聚合起始点 A 开始，对非功能性单体进行辐射聚合，以生长非功能性聚合物链；步骤 3：在形成非功能性聚合物链的物体表面形成聚合起始点 B；以及步骤 4：从聚合起始点 B 开始，对功能性单体进行辐射聚合，以生长功能性聚合物链。
• SURFACE-MODIFIED RUBBER OF SURFACE-MODIFIED THERMOPLASTIC ELASTOMER AND METHOD FOR MODIFYING SURFACE OF RUBBER OR THERMOPLASTIC ELASTOMER
  申请人：Sumitomo Rubber Industries, Ltd.

  公开号：EP3037114A1

  公开（公告）日：2016-06-29

  Provided are surface-modified rubbers or surface-modified thermoplastic elastomers, such as catheters, syringe barrels, tubes of medical instruments, and mudguard fenders, and methods for modifying the surface of rubber or a thermoplastic elastomer, wherein a lubricant layer is firmly bonded to the surface of medical devices such as catheters, syringe barrels, and tubes of medical instruments to impart lubricity to the surface and, further, improve the durability of the lubricant layer on the surface, thereby suppressing deterioration of the sliding properties. Included is a surface-modified rubber or a surface-modified thermoplastic elastomer each having a surface at least partially treated by polymerization of a monomer in the presence of a thermal polymerization initiator.

  本发明提供了表面改性橡胶或表面改性热塑性弹性体，如导管、注射器筒、医疗器械管和挡泥板，以及用于改性橡胶或热塑性弹性体表面的方法，其中润滑剂层被牢固地粘合到医疗器械（如导管、注射器筒和医疗器械管）的表面，以赋予表面润滑性，并进一步提高表面润滑剂层的耐久性，从而抑制滑动性能的恶化。其中包括表面改性橡胶或表面改性热塑性弹性体，每种橡胶或弹性体的表面至少部分经过单体在热聚合引发剂存在下的聚合处理。
• SURFACE-MODIFIED METAL AND METHOD FOR MODIFYING METAL SURFACE
  申请人：SUMITOMO RUBBER INDUSTRIES, LTD.

  公开号：EP3037113A1

  公开（公告）日：2016-06-29

  Provided are surface-modified metals such as metal medical devices e.g., guide wires, syringe needles, and metal tubes in medical devices or equipment, and methods for modifying a metal surface, wherein a lubricant layer is firmly bonded to the surface to impart lubricity to the surface and, further, improve the durability of the lubricant layer on the surface, thereby suppressing deterioration of the sliding properties. Included is a surface-modified metal having a surface at least partially treated by polymerization of a monomer in the presence of a thermal polymerization initiator.

  本发明提供了表面改性金属，例如金属医疗器械，如医疗器械或设备中的导丝、注射器针头和金属管，以及改性金属表面的方法，其中润滑剂层牢固地粘合在表面上，以赋予表面润滑性，并进一步提高表面润滑剂层的耐久性，从而抑制滑动性能的恶化。其中包括一种表面改性金属，其表面至少部分是在热聚合引发剂存在下通过单体聚合处理的。
• SPECIFIC CELL FRACTIONATING AND CAPTURING METHODS
  申请人：Sumitomo Rubber Industries, Ltd.

  公开号：EP3686598A1

  公开（公告）日：2020-07-29

  Provided are specific cell-fractionating and - capturing methods which can fractionate and capture, respectively, specific cells (e.g., many types of cancer cells, including cancer cells not expressing EpCAM, or peripheral blood stem cells). Included is a method for fractionating specific cells present in blood or biological fluid, the method including fractionating the blood or biological fluid by centrifugation to collect the specific cells in the blood or biological fluid, the centrifugation being carried out using a container having a low protein adsorbing layer at least partially formed on the inner surface thereof.

  本发明提供了特异性细胞分馏和捕获方法，可分别分馏和捕获特异性细胞（例如，多种类型的癌细胞，包括不表达EpCAM的癌细胞或外周血干细胞）。该方法包括通过离心分离血液或生物流体以收集血液或生物流体中的特定细胞，离心分离使用的容器至少部分在其内表面形成低蛋白吸附层。
• Metal medical device
  申请人：SUMITOMO RUBBER INDUSTRIES, LTD.

  公开号：US10092680B2

  公开（公告）日：2018-10-09

  The present invention provides metal medical devices which are provided with sliding properties (lubricity), low protein adsorption properties and low cell adsorption properties and further in which these properties are prevented from deteriorating. The present invention relates to a metal medical device having a surface at least partially treated with a copolymer C of a polymerizable silane compound A and a polymerizable compound B that contains a functional group.

  本发明提供的金属医疗器械具有滑动性能（润滑性）、低蛋白吸附性能和低细胞吸附性能，并能进一步防止这些性能恶化。本发明涉及一种金属医疗器械，其表面至少部分经过可聚合硅烷化合物 A 和含有官能团的可聚合化合物 B 的共聚物 C 的处理。