(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris(3-azidopropoxy)-10,13-dimethyl-17-[(2R)-5-methylsulfonylpentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris(3-azidopropoxy)-10,13-dimethyl-17-[(2R)-5-methylsulfonylpentan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
• 化学式: C34H59N9O5S
• 分子量: 706.0
• InChiKey: JBIMWRIXYVHIJW-XRCUTWBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  49
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• CATIONIC STEROIDAL ANTIMICROBIAL SALTS
  申请人：Savage Paul B.

  公开号：US20160311850A1

  公开（公告）日：2016-10-27

  Disclosed herein are acid addition salts of cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making the same. Particularly advantageous salt forms are identified, such as 1,5-naphthalenedisulfonic acid addition salts and sulfate addition salts. The acid addition salts may be formulated for treating subjects with ailments responsive to CSAs, including but not limited to treating bacterial infections. Accordingly, some embodiments include formulations and methods of administering acid addition salts of CSAs.

  本发明涉及阳离子类固醇抗微生物剂（“CSAs”或“ceragenins”）的酸盐和制备方法。特别有利的盐形式被确定，例如1,5-萘二磺酸盐和硫酸盐。这些酸盐可以用于治疗对CSAs有反应的患者，包括但不限于治疗细菌感染。因此，一些实施例包括CSAs的酸盐配方和给药方法。
• METHODS FOR REDUCING CELLULAR PROLIFERATION AND TREATING CERTAIN DISEASES
  申请人：Genberg Carl

  公开号：US20140194401A1

  公开（公告）日：2014-07-10

  Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.
• US20140274913A1
  申请人：——

  公开号：US20140274913A1

  公开（公告）日：2014-09-18
• METHODS FOR TREATING INFLAMMATION, AUTOIMMUNE DISORDERS AND PAIN
  申请人：Savage Paul B.

  公开号：US20140336131A1

  公开（公告）日：2014-11-13

  Disclosed herein are methods of treating, reducing, or preventing a disease such as oral mucositis, gastric mucositis, or inflammatory fibrosis, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.
• METHODS FOR TREATING LUNG INFECTIONS AND INFLAMMATION
  申请人：SAVAGE PAUL B.

  公开号：US20150110767A1

  公开（公告）日：2015-04-23

  Methods of treating, reducing, or preventing lung infections or lung inflammation include identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Treatment of cystic fibrosis lung infections, COPD lung infections, inflammation of the lungs in these patient populations, and lung scarring in these patient populations is also described.