2-Benzyl-3-methyl-1,2-dihydropyridine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Benzyl-3-methyl-1,2-dihydropyridine
• 英文别名: 2-benzyl-3-methyl-1,2-dihydropyridine
• 化学式: C₁₃H₁₅N
• 分子量: 185.26
• InChiKey: MRHWIOIHDCHPJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] C-TERMINAL HSP90 INHIBITORS TO TREAT PITUITARY ADENOMAS<br/>[FR] INHIBITEURS DE HSP90 DE LIAISON AU DOMAINE C-TERMINAL POUR LE TRAITEMENT D'ADÉNOMES PITUITAIRES
  申请人：MAX PLANCK GES ZUR FÖRDERUNG DER WISSENSCHAFT E V

  公开号：WO2014106623A1

  公开（公告）日：2014-07-10

  The present invention relates to C-terminal HSP90 inhibitors, like silibinin, novobiocin and derivatives thereof, stereoisomeric forms, prodrugs, solvates, hydrates and/or pharmaceutically acceptable salts of these compounds as well as pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said compounds and its compositions have been identified as useful for the treatment of pituitary adenomas such as corticotroph adenomas, lactotroph adenomas, somatotroph adenomas and thyrotroph adenomas.