4-[[[Amino-[(2-methylpropan-2-yl)oxycarbonyl]amino]-[(2-methylpropan-2-yl)oxycarbonylamino]methylidene]amino]-5-methylcyclohexa-1,3-diene-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-[[[Amino-[(2-methylpropan-2-yl)oxycarbonyl]amino]-[(2-methylpropan-2-yl)oxycarbonylamino]methylidene]amino]-5-methylcyclohexa-1,3-diene-1-carboxylic acid
• 英文别名: 4-[[[amino-[(2-methylpropan-2-yl)oxycarbonyl]amino]-[(2-methylpropan-2-yl)oxycarbonylamino]methylidene]amino]-5-methylcyclohexa-1,3-diene-1-carboxylic acid
• 化学式: C₁₉H₃₀N₄O₆
• 分子量: 410.5
• InChiKey: JWACKBFXVXUYTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  144
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• GUANIDINOBENZOIC ACID COMPOUND
  申请人：Astellas Pharma Inc.

  公开号：EP2757093A1

  公开（公告）日：2014-07-23

  [Problem] Provided is a compound which is useful as an agent for preventing and/or treating renal diseases. [Means for Solution] The present inventors have conducted extensive studies on compounds having a trypsin inhibitory action, and as a result, they have found that a guanidinobenzoic acid compound has a trypsin inhibitory action, thereby completing the present invention. The guanidinobenzoic acid compound of the present invention can be used as an agent for preventing and/or treating renal disease as an agent which will substitute low-protein diet therapy, and an agent for preventing and/or treating trypsin-related diseases, for example, pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like.

  问题 本发明提供了一种可作为预防和/或治疗肾脏疾病的药物的化合物。 [解决方法］ 本发明人对具有胰蛋白酶抑制作用的化合物进行了广泛的研究，结果发现一种胍基苯甲酸化合物具有胰蛋白酶抑制作用，从而完成了本发明。本发明的胍基苯甲酸化合物可用作预防和/或治疗肾病的制剂，作为替代低蛋白饮食疗法的制剂，还可用作预防和/或治疗胰蛋白酶相关疾病的制剂，例如胰腺炎、胃食管反流病、肝性脑病、流感等。