3-Methyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-Methyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridine
• 英文别名: 3-methyl-1,2,5,6,7,8-hexahydro-1,6-naphthyridine
• 化学式: C₉H₁₄N₂
• 分子量: 150.22
• InChiKey: SLPIWNBITRLRMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• RHO KINASE INHIBITORS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2114869B1

  公开（公告）日：2014-07-23
• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：GENENTECH INC

  公开号：WO2017205536A2

  公开（公告）日：2017-11-30

  The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R5-R6 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.