N'-chloropentane-1,5-diamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N'-chloropentane-1,5-diamine
• 化学式: C₅H₁₃ClN₂
• 分子量: 136.62
• InChiKey: ZKQSZQDEYMRBII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• PURIFICATION OF CADAVERINE USING HIGH BOILING POINT SOLVENT
  申请人：CATHAY R&D CENTER CO., LTD.

  公开号：US20150368185A1

  公开（公告）日：2015-12-24

  One aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine composition comprising one or more involatile impurities, the method comprising obtaining cadaverine from evaporation or distillation of the aqueous cadaverine composition wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation starts, during the evaporation/distillation and/or after the evaporation/distillation substantially stops when no more evaporation/distillation is observed; wherein the one or more solvents comprise at least one or more high boiling point (HBP) solvents. In certain embodiments, cadaverine may be evaporated/distilled at an unexpectedly lower heating temperature for an unexpectedly shorter heating time to provide a desired yield. Because cadaverine may decompose at high temperature, the unexpectedly lower heating temperature and unexpectedly shorter heating time decrease the undesired cadaverine decomposition. The methods disclosed herein provides unexpected high recovery rate (˜100%) in the evaporation/distillation of cadaverine at a larger scale at a lower heating temperature compared to conventional distillation methods. Thus, the method disclosed herein will be highly appreciated in the industrial production of cadaverine.

  本发明的一个方面涉及从含有一种或多种不挥发杂质的水溶性腐胺组成物中纯化腐胺的方法，该方法包括从水溶性腐胺组成物的蒸发或蒸馏中获取腐胺，在蒸发/蒸馏开始之前、蒸发/蒸馏期间和/或蒸发/蒸馏基本停止时向蒸发/蒸馏系统中添加一个或多个溶剂，其中一个或多个溶剂包括至少一个或多个高沸点（HBP）溶剂。在某些实施例中，可以以意外较低的加热温度和意外较短的加热时间蒸发/蒸馏腐胺以提供所需的产量。由于腐胺可能在高温下分解，因此意外较低的加热温度和意外较短的加热时间减少了不必要的腐胺分解。本文所披露的方法在较大规模的腐胺蒸发/蒸馏中以较低的加热温度提供了意外的高回收率（约为100%），与传统蒸馏方法相比。因此，本文所披露的方法在腐胺的工业生产中将受到高度赞赏。
• PURIFICATION OF CADAVERINE
  申请人：CATHAY R&D CENTER CO., LTD.

  公开号：US20150368184A1

  公开（公告）日：2015-12-24

  One aspect of the invention relates to a method for reducing salt content in an aqueous cadaverine salt composition comprising adjusting the pH of the aqueous cadaverine salt composition to provide a first composition comprising an aqueous cadaverine composition and a solid composition, and removing the solid composition from the first composition to provide the aqueous cadaverine composition. Another aspect of the invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition using the salt-reducing method described herein; and obtaining cadaverine from the aqueous cadaverine composition.

  该发明的一个方面涉及一种减少水相腐胺盐组成中盐含量的方法，包括调节水相腐胺盐组成的pH值，以提供包含水相腐胺组成和固体组成的第一组成物，并从第一组成物中除去固体组成，以提供水相腐胺组成。该发明的另一个方面涉及使用上述减盐方法从水相腐胺盐组成中纯化腐胺的方法，并从水相腐胺组成中获取腐胺。
• Purification of cadaverine using high boiling point solvent
  申请人：CATHAY R&D CENTER CO., LTD.

  公开号：US10464880B2

  公开（公告）日：2019-11-05

  The present invention relates to a method for the purification of cadaverine from an aqueous cadaverine salt composition comprising one or more involatile impurities, the method comprising: (1) mixing the aqueous cadaverine salt composition with one or more bases to provide an aqueous cadaverine composition having a pH of at least about 12; (2) distilling or evaporating the aqueous cadaverine composition to produce an aqueous cadaverine solution, wherein one or more solvents are added to the evaporation/distillation system before the evaporation/distillation stops, and the one or more solvents comprise at least one or more high boiling point (HBP) solvents having a boiling point of at least 185° C. (1 atm); and (3) subjecting the aqueous cadaverine solution to one or more rectification steps to provide a cadaverine product.

  本发明涉及一种从含有一种或多种不挥发性杂质的水性尸胺盐组合物中提纯尸胺的方法，该方法包括：(1) 将水性尸胺盐组合物与一种或多种碱混合，以提供 pH 值至少约为 12 的水性尸胺组合物；(2) 蒸馏或蒸发水性尸胺组合物，以产生尸胺水溶液，其中在蒸发/蒸馏停止之前，将一种或多种溶剂加入蒸发/蒸馏系统，且一种或多种溶剂包括至少一种或多种高沸点（HBP）溶剂，其沸点至少为 185°C.(1 atm)；以及 (3) 将尸胺水溶液进行一个或多个精馏步骤，以提供尸胺产品。
• PREPARATION OF CADAVERINE
  申请人：CATHAY R&D CENTER CO., LTD.

  公开号：US20170121273A1

  公开（公告）日：2017-05-04

  The invention relates to a method for preparing cadaverine comprising: (1) obtaining an aqueous cadaverine salt composition from a fermentation system; (2) adjusting the pH of the aqueous cadaverine salt composition to a pH of at least about 12 by adding an inorganic base composition to provide a first composition comprising an aqueous cadaverine composition having a pH of at least about 12 and a solid composition comprising one or more alkali metal sulfates; (3) subjecting the first composition to solid-liquid separation without organic solvent extraction to provide the aqueous cadaverine composition and the solid composition; (4) distilling or evaporating the aqueous cadaverine composition of step (3) without organic solvent extraction to provide purified cadaverine; (5) preparing a saturated solution of the alkali metal sulfate(s) from the solid composition of step (3) at a temperature of about 35-40° C., mixing the saturated solution with NH 4 HCO 3 , and subjecting the mixture to solid-liquid separation to provide Solution (I) and Solid (I); (6) adjusting the temperature of Solution (I) to about 60-80° C., and obtaining Solution (II) and Solid (II) after solid-liquid separation; (7) concentrating Solution (II) and obtaining Solution (III) and Solid (III) after solid-liquid separation; and (8) adding Solid (III) back to the fermentation system of step (1); wherein steps (1) to (8) are optionally repeated one or more times.
• US9546127B2
  申请人：——

  公开号：US9546127B2

  公开（公告）日：2017-01-17