5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-(4-chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-isopropyl-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one | 1620845-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-(4-chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-isopropyl-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one
• 英文别名: 5-(5-Chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-(4-chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-isopropyl-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one；5-(5-chloro-1-methyl-6-oxopyridin-3-yl)-4-(4-chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4,7-dihydropyrazolo[3,4-d]pyrimidin-6-one
• CAS: 1620845-20-6
• 化学式: C₂₇H₂₇Cl₂N₇O₄
• 分子量: 584.462
• InChiKey: QPKZOSFMRPOCJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(5-(aminomethyl)-2-methoxyphenyl)-4-(4-chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-3-isopropyl-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one 、 2-(5-(aminomethyl)-2-methoxyphenyl)-5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-(4-chloro-2-methylphenyl)-3-isopropyl-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one 、 5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-(4-chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-isopropyl-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one 、 5-(5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-4-(4-chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-isopropyl-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one 生成 4-(4-Chloro-2-methylphenyl)-5-(1-ethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-isopropyl-2-(2-methoxyphenyl)-4,5-dihydro-2H-pyrazolo[3,4-d]pyrimidin-6(7H)-one
  参考文献：
  名称：

  PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION

  摘要：

  本发明涉及公式(I)的化合物，如本文所述，包括这些化合物的药物制剂，在治疗由MDM2和/或MDM4活性介导的疾病或紊乱中使用这些化合物的用途和方法，以及包含这些化合物的组合物。

  公开号：

  US20150353563A1

文献信息

• [EN] PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION<br/>[FR] COMPOSÉS PYRAZOLO[3,4-D]PYRIMIDINONE UTILISÉS EN TANT QU'INHIBITEURS DE L'INTERACTION P53/MDM2
  申请人：NOVARTIS AG

  公开号：WO2014115080A1

  公开（公告）日：2014-07-31

  The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

  本发明涉及式(I)的化合物，如本文所述，包括这种化合物的药物制剂，以及在治疗由MDM2和/或MDM4活性介导的疾病或疾病中使用这种化合物的用途和方法，以及包括这种化合物的组合物。
• US9556180B2
  申请人：——

  公开号：US9556180B2

  公开（公告）日：2017-01-31
• PYRAZOLO[3,4-D]PYRIMIDINONE COMPOUNDS AS INHIBITORS OF THE P53/MDM2 INTERACTION
  申请人：FURET Pascal

  公开号：US20150353563A1

  公开（公告）日：2015-12-10

  The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.

  本发明涉及公式(I)的化合物，如本文所述，包括这些化合物的药物制剂，在治疗由MDM2和/或MDM4活性介导的疾病或紊乱中使用这些化合物的用途和方法，以及包含这些化合物的组合物。