tert-butyl 2-(4-((5-chloro-1-isopentyl-1H-imidazo[4,5-b]pyridin-2-yl)methyl)-3-oxo-3,4-dihydroquinoxalin-6-yl)-1H-pyrrole-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: tert-butyl 2-(4-((5-chloro-1-isopentyl-1H-imidazo[4,5-b]pyridin-2-yl)methyl)-3-oxo-3,4-dihydroquinoxalin-6-yl)-1H-pyrrole-1-carboxylate
• 英文别名: Tert-butyl 2-[4-[[5-chloro-1-(3-methylbutyl)imidazo[4,5-b]pyridin-2-yl]methyl]-3-oxoquinoxalin-6-yl]pyrrole-1-carboxylate；tert-butyl 2-[4-[[5-chloro-1-(3-methylbutyl)imidazo[4,5-b]pyridin-2-yl]methyl]-3-oxoquinoxalin-6-yl]pyrrole-1-carboxylate
• 化学式: C₂₉H₃₁ClN₆O₃
• 分子量: 547.057
• InChiKey: ZWWMWSGRVWAZCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  94.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS<br/>[FR] QUINOXALINONES ET DIHYDROQUINOXALINONES EN TANT QU'AGENTS ANTIVIRAUX CONTRE VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：JANSSEN R & D IRELAND

  公开号：WO2014114776A1

  公开（公告）日：2014-07-31

  Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula (I) including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

  喹诺醌酮和二氢喹诺醌酮具有对RSV复制具有抑制活性的公式（I），包括加成盐和立体化学异构体形式；含有这些化合物作为活性成分的组合物以及制备这些化合物和组合物的过程。
• QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
  申请人：Janssen Sciences Ireland UC

  公开号：EP2948444B1

  公开（公告）日：2016-12-07
• QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS
  申请人：Janssen Sciences Ireland UC

  公开号：US20170260166A1

  公开（公告）日：2017-09-14

  Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.