3-[6-(Difluoromethoxy)pyridin-3-yl]-3-[2-oxo-3-[[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)oxetan-3-yl]methyl]imidazolidin-1-yl]propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[6-(Difluoromethoxy)pyridin-3-yl]-3-[2-oxo-3-[[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)oxetan-3-yl]methyl]imidazolidin-1-yl]propanoic acid
• 英文别名: 3-[6-(difluoromethoxy)pyridin-3-yl]-3-[2-oxo-3-[[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)oxetan-3-yl]methyl]imidazolidin-1-yl]propanoic acid
• 化学式: C₂₅H₂₉F₂N₅O₅
• 分子量: 517.5
• InChiKey: OVVIKXJJGBLSFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Fluorinated 3-(2-Oxo-3-(3-Arylpropyl)Imidazolidin-1-yl)-3-Arylpropanoic Acid Derivatives
  申请人：SciFluor Life Sciences, LLC

  公开号：US20140221410A1

  公开（公告）日：2014-08-07

  The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives and pharmaceutically acceptable salts or solvates thereof and their use are described.

  这项发明涉及氟化合物及其作为整合素受体拮抗剂的用途。描述了新型氟化3-(2-氧-3-(3-芳基丙基)咪唑啉-1-基)-3-芳基丙酸衍生物及其药用可接受盐或溶剂，以及它们的用途。
• FLUORINATED INTEGRIN ANTAGONISTS
  申请人：SCIFLUOR LIFE SCIENCES, INC.

  公开号：US20160075698A1

  公开（公告）日：2016-03-17

  The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及式I的氟化合物及其合成方法。本发明还涉及含有本发明的氟化合物的药物组合物，并通过将这些化合物和药物组合物给予需要治疗黄斑变性、糖尿病视网膜病变（DR）、黄斑水肿、糖尿病性黄斑水肿（DME）和视网膜静脉阻塞后的黄斑水肿（RVO）的受试者来治疗这些疾病。
• FLUORINATED 3-(2-OXO-3-(3-ARYLPROPYL)IMIDAZOLIDIN-1-YL)-3-ARYLPROPANOIC ACID DERIVATIVES
  申请人：SciFluor Life Sciences, Inc.

  公开号：US20160130270A1

  公开（公告）日：2016-05-12

  The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives and pharmaceutically acceptable salts or solvates thereof and their use are described.

  本发明涉及氟化合物及其作为整合素受体拮抗剂的用途。本发明描述了新型氟化3-(2-氧代-3-(3-芳基丙基)咪唑啉-1-基)-3-芳基丙酸衍生物及其药学上可接受的盐或溶剂，以及它们的用途。
• Fluorinated integrin antagonists
  申请人：SciFluor Life Sciences, Inc.

  公开号：US10106537B2

  公开（公告）日：2018-10-23

  The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及式 I 的含氟化合物以及合成这些化合物的方法。本发明还涉及含有本发明含氟化合物的药物组合物，以及通过向有需要的受试者施用这些化合物和药物组合物来治疗黄斑变性、糖尿病视网膜病变（DR）、黄斑水肿、糖尿病黄斑水肿（DME）和视网膜静脉闭塞（RVO）后黄斑水肿的方法。
• US8901144B2
  申请人：——

  公开号：US8901144B2

  公开（公告）日：2014-12-02