3-[3-[6-(Difluoromethoxy)pyridin-3-yl]-2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]imidazol-3-ium-1-yl]propanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[3-[6-(Difluoromethoxy)pyridin-3-yl]-2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]imidazol-3-ium-1-yl]propanoate
• 英文别名: 3-[3-[6-(difluoromethoxy)pyridin-3-yl]-2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]imidazol-3-ium-1-yl]propanoate
• 化学式: C23H25F2N5O4
• 分子量: 473.5
• InChiKey: PIXJXWKFXBMIMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Fluorinated 3-(2-Oxo-3-(3-Arylpropyl)Imidazolidin-1-yl)-3-Arylpropanoic Acid Derivatives
  申请人：SciFluor Life Sciences, LLC

  公开号：US20140221410A1

  公开（公告）日：2014-08-07

  The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives and pharmaceutically acceptable salts or solvates thereof and their use are described.

  这项发明涉及氟化合物及其作为整合素受体拮抗剂的用途。描述了新型氟化3-(2-氧-3-(3-芳基丙基)咪唑啉-1-基)-3-芳基丙酸衍生物及其药用可接受盐或溶剂，以及它们的用途。
• FLUORINATED 3-(2-OXO-3-(3-ARYLPROPYL)IMIDAZOLIDIN-1-YL)-3-ARYLPROPANOIC ACID DERIVATIVES
  申请人：SciFluor Life Sciences, Inc.

  公开号：US20170096427A1

  公开（公告）日：2017-04-06

  The invention relates to fluorinated compounds and their use as integrin receptor antagonists. Novel fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives and pharmaceutically acceptable salts or solvates thereof and their use are described.
• US8901144B2
  申请人：——

  公开号：US8901144B2

  公开（公告）日：2014-12-02
• US9266884B2
  申请人：——

  公开号：US9266884B2

  公开（公告）日：2016-02-23