N-[2-(3,4-dihydroxyphenyl)ethyl]-2-sulfanylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-[2-(3,4-dihydroxyphenyl)ethyl]-2-sulfanylacetamide
• 化学式: C₁₀H₁₃NO₃S
• 分子量: 227.28
• InChiKey: HQQCASJAVXCYLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  70.6
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• COATING FOR SUBSTRATE
  申请人：W. L. Gore & Associates, Inc.

  公开号：EP2950832B1

  公开（公告）日：2018-08-01
• NO RELEASING COATED PROSTHETIC VASCULAR GRAFTS
  申请人：University of Georgia Research Foundation, Inc.

  公开号：EP3826628A1

  公开（公告）日：2021-06-02
• [EN] COATING FOR SUBSTRATE<br/>[FR] REVÊTEMENT POUR SUBSTRAT
  申请人：GORE & ASS

  公开号：WO2014118382A1

  公开（公告）日：2014-08-07

  There is provided inter alia a substrate with a surface having a hydrophilic coating comprising a cross-linked copolymer of components A and B, and optional components C and D; wherein component A comprises one or more C2-C16 hydrophilic monomers each bearing one or more alkene and/or alkyne groups; component B comprises one or more hydrophilic polymers each bearing two or more alkene and/or alkyne groups; component C, if present, comprises one or more beneficial agents each bearing one or more alkene or alkyne groups; and component D, if present, comprises one or more low molecular weight cross-linking agents each bearing two or more functional groups independently selected from thiol, alkene and alkyne groups; wherein the cross-linked copolymer is formed by radical polymerisation involving the alkene and/or alkyne groups of components A, B and C (if present) and involving the functional groups of component D (if present); wherein the hydrophilic coating optionally comprises component E which comprises one or more beneficial agents, wherein component E does not form a copolymer with components A, B, C (if present) and D (if present); and wherein the hydrophilic coating is covalently attached to the surface of the substrate.
• [EN] NO RELEASING COATED PROSTHETIC VASCULAR GRAFTS<br/>[FR] GREFFONS VASCULAIRES PROTHÉTIQUES À REVÊTEMENT NON DÉTACHABLE
  申请人：UNIV GEORGIA

  公开号：WO2020041617A1

  公开（公告）日：2020-02-27

  A variety of nitric oxide-releasing vascular grafts and prostheses are provided. Methods of making the nitric oxide-releasing vascular grafts and prostheses are also provided. Methods of administering the nitric oxide-releasing vascular grafts and prostheses to a subject in need thereof are also provided. The nitric oxide-releasing vascular grafts and prostheses have a base layer made of a graft material and a nitric oxide-releasing layer made from a polymer matrix including a plurality of polysiloxanes and a plurality of nitric oxide-donating crosslinking moieties covalently crosslinking polysiloxanes in the plurality of polysiloxanes. In some aspects, the vascular grafts and prostheses can provide for reduced infection rates and increased patency by providing for prolonged local delivery of nitric oxide when implanted in a vessel of a subject in need thereof.