(2S)-dodecan-2-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2S)-dodecan-2-amine
• 化学式: C₁₂H₂₇N
• 分子量: 185.35
• InChiKey: VXUXKOBYNVVANW-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• NOVEL PYRAZOLE DERIVATIVE
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：US20140378448A1

  公开（公告）日：2014-12-25

  It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g. mental disorder and neurodegenerative disorder). The present invention provides: compounds having PDE10 inhibitory effect, in particular, compounds having a 4-heteroarylpyrazole-5-carboxylic acid amide structure represented by the following formula (I), or their pharmaceutically acceptable salts, or their solvates; pharmaceutical compositions comprising, as active ingredients, the compounds, or their pharmaceutically acceptable salts, or their solvates; and medical use of the compounds, or their pharmaceutically acceptable salts, or their solvates.

  本发明旨在开发一种药物组合物，用于预防和/或治疗与PDE10相关的各种疾病（例如精神障碍和神经退行性疾病）的药剂。本发明提供以下内容：具有PDE10抑制作用的化合物，特别是具有下列式（I）所代表的4-杂环芳基吡唑-5-羧酸酰胺结构的化合物，或其药学上可接受的盐或其溶剂；包含上述化合物或其药学上可接受的盐或其溶剂作为活性成分的制药组合物；以及上述化合物或其药学上可接受的盐或其溶剂的医疗用途。
• Process for producing at least one metabolite of interest by conversion of a pentose in a microorganism
  申请人：INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE—INRA

  公开号：US10570423B2

  公开（公告）日：2020-02-25

  Disclosed is a process for producing at least one metabolite of interest by conversion of a pentose in a microorganism. The process includes at least: (i) an operation of culturing a recombinant microorganism expressing a synthetic pathway for pentose assimilation which includes at least the following steps: a) phosphorylation in position 1 of a pentose chosen from (D)-xylulose and/or (L)-ribulose, b) cleavage of the pentose-1-phosphate obtained at the end of step a), in order to obtain glycolaldehyde and dihydroxyacetone phosphate (DHAP), and (ii) an operation of recovering the at least one metabolite of interest obtained at the end of the culturing operation (i). Also disclosed is an associated microorganism.

  本发明公开了一种在微生物中通过戊糖转化生产至少一种相关代谢物的工艺。该工艺至少包括：(i) 培养表达戊糖同化合成途径的重组微生物的操作，该操作至少包括以下步骤：a) 在选自(D)-木酮糖和/或(L)-核酮糖的戊糖的第 1 位进行磷酸化，b) 裂解在步骤 a)结束时获得的戊糖-1-磷酸，以获得乙醛和磷酸二羟丙酮（DHAP），以及 (ii) 回收在培养操作 (i) 结束时获得的至少一种相关代谢物的操作。还公开了一种相关微生物。