1-[3-(Ethylamino)-2-hydroxypropoxy]butan-2-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[3-(Ethylamino)-2-hydroxypropoxy]butan-2-ol
• 英文别名: 1-[3-(ethylamino)-2-hydroxypropoxy]butan-2-ol
• 化学式: C₉H₂₁NO₃
• 分子量: 191.27
• InChiKey: SHYRSTFJKVRIDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61.7
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Affinity chromatography matrix
  申请人：Laboratoire Français du Fractionnement et des Biotechnologies

  公开号：US10611826B2

  公开（公告）日：2020-04-07

  The invention relates to an affinity chromatography matrix, as a gel, comprising polymeric particles on which at least one oligosaccharide corresponding to a blood group A epitope and/or blood group B is grafted, via a spacer, characterized in that the density of oligosaccharides is comprised between 0.2 and 0.7 mg/ml of matrix. The invention also relates to the uses of this matrix for preparing concentrates of immunoglobulins for therapeutic use.

  本发明涉及一种凝胶状的亲和层析基质，该基质由聚合物颗粒组成，在聚合物颗粒上通过间隔接枝了至少一种与血型 A 表位和/或血型 B 相对应的寡糖，其特征在于寡糖的密度在 0.2 至 0.7 毫克/毫升基质之间。本发明还涉及这种基质在制备治疗用免疫球蛋白浓缩物中的用途。
• Composition Enriched in Anti-A and /or Anti B Polyclonal Immunoglobulins
  申请人：Laboratoire Francais du Fractionnement et des Biotechnologies

  公开号：US20180100023A1

  公开（公告）日：2018-04-12

  The present invention relates to a composition highly enriched in anti-A and/or anti-B polyclonal immunoglobulins, comprising human polyclonal immunoglobulins, characterized in that at least 80% by weight of the human polyclonal immunoglobulins present in the composition are human anti-A and/or anti-B polyclonal immunoglobulins. The invention also relates to a method for preparing such a composition, and to the use of the composition for preparing a positive control that can be used in a method for assaying anti-A and/or anti-B activity of human normal immunoglobulins, and to use of the composition for determining an individual's blood type.
• COMPOSITION ENRICHED IN ANTI-A AND/OR ANTI-B POLYCLONAL IMMUNOGLOBULINS FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES OR POLYCYTHEMIA
  申请人：Laboratoire Francais du Fractionnement et des Biotechnologies

  公开号：US20180142036A1

  公开（公告）日：2018-05-24

  The invention relates to a composition strongly enriched with anti-A and/or anti-B polyclonal immunoglobulins, comprising polyclonal human immunoglobulins, characterised in that at least 80 wt.-% of the polyclonal human immunoglobulins present in the composition are anti-A or anti-B polyclonal human immunoglobulins, for use as a drug, particularly in the treatment of polycythemia and/or autoimmune diseases, and in particular peripheral autoimmune thrombocytopenia.
• US8802448B2
  申请人：——

  公开号：US8802448B2

  公开（公告）日：2014-08-12