N-[[3-(1-amino-1,5-dioxopentan-2-yl)-2-methyl-4-oxoquinazolin-6-yl]methyl]-4-(trifluoromethyl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[[3-(1-amino-1,5-dioxopentan-2-yl)-2-methyl-4-oxoquinazolin-6-yl]methyl]-4-(trifluoromethyl)benzamide
• 化学式: C₂₃H₂₁F₃N₄O₄
• 分子量: 474.4
• InChiKey: DTZKWTMAACLPBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• 6-, 7-, OR 8-SUBSTITUTED QUINAZOLINONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
  申请人：CELGENE CORPORATION

  公开号：EP2200999B1

  公开（公告）日：2014-08-13
• [EN] COMBINATION THERAPY COMPRISING A TOR KINASE INHIBITOR AND A 5-SUBSTITUTED QUINAZOLINONE COMPOUND FOR TREATING CANCER<br/>[FR] POLYTHÉRAPIE COMPRENANT UN INHIBITEUR DE KINASE TOR ET UN COMPOSÉ DE QUINAZOLINONE SUBSTITUÉ EN 5 POUR LE TRAITEMENT DU CANCER
  申请人：SIGNAL PHARM LLC

  公开号：WO2014172436A1

  公开（公告）日：2014-10-23

  Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount of a 5- Substituted Quinazolinone Compound to a patient having a cancer.
• [EN] METHODS FOR TREATING CANCER USING COMBINATION THERAPY<br/>[FR] MÉTHODES DE TRAITEMENT DU CANCER À L'AIDE D'UNE POLYTHÉRAPIE
  申请人：CELGENE CORP

  公开号：WO2014179661A1

  公开（公告）日：2014-11-06

  Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a substituted quinazolinone compound and an effective amount of N-(3 -(5 -fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4- ylamino)phenyl)acrylamide to a patient having a cancer.