2,2,5-Trimethyl-4-propan-2-yloxyfuran-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 2,2,5-Trimethyl-4-propan-2-yloxyfuran-3-one
• 英文别名: 2,2,5-trimethyl-4-propan-2-yloxyfuran-3-one
• 化学式: C₁₀H₁₆O₃
• 分子量: 184.23
• InChiKey: GXYCJPOHZOMTQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHOD FOR GENERATING HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF
  申请人：Dekany Gyula

  公开号：US20140234912A1

  公开（公告）日：2014-08-21

  A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a), b) and c); and e) incubating the mixture prepared according to step d).

  一种生成人乳寡糖（HMO）或其前体的方法，该方法包括以下步骤：a）提供至少一种来自公式5至10中的化合物组的供体；b）提供至少一种来自乳糖、LNT、LNnT及其衍生物组的受体；c）提供至少一种具有转床苷酶活性和/或糖合成酶活性的酶；d）制备在步骤a）、b）和c）中提供的至少一种供体、至少一种受体和至少一种酶的混合物；e）孵育根据步骤d）制备的混合物。该方法所得到的化合物，以及使用该化合物的组合物和用途也包括在内。
• Synthesis of sialylated/fucosylated human milk oligosaccharides
  申请人：GLYCOM A/S

  公开号：US10005807B2

  公开（公告）日：2018-06-26

  An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

  提出了一种酶法合成式 1 寡糖的方法，其中 R 选自-OH、-N 3 和-OR 6，其中 R 6 选自任选被一个或多个甲基取代的烯丙基、任选被一个或多个甲基取代的丙炔基、2-三甲基硅基-乙基、-(CH 2) n -NH 2 和-(CH 2) n -N 3，其中整数 n 为 10，优选 2 或 3，R 选自硅戊基、-SO 3 H 和 -CH(R)-COOH 其中 R 选自 H、烷基和苄基，R 2 选自 H 和岩藻糖基，R 3 选自 H 和硅烷基，R 4 选自 H 和岩藻糖基，条件是 R 3 和 R 4 中至少有一个是 H，且 A 是二价碳水化合物连接体，对制药和食品工业具有重要的生物活性和巨大的商业价值。
• SYNTHESIS OF NEW FUCOSE-CONTAINING CARBOHYDRATE DERIVATIVES
  申请人：Glycom A/S

  公开号：US20140228554A1

  公开（公告）日：2014-08-14

  A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R 1 or a salt thereof, wherein A and R 1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.
• METHOD FOR ENZYMATIC GLYCOSYLATION OF OLIGOSACCHARIDES FROM MAMMALIAN ANIMAL MILK
  申请人：Glycom A/S

  公开号：US20150182549A1

  公开（公告）日：2015-07-02

  A method for modifying galactosyl disaccharides in order to enhance their bifidogenic effect, comprising reacting at least one glycosyl donor with a precursor galactosyl disaccharide or a mixture of precursor galactosyl disaccharides using enzyme catalysis, compounds obtainable by said method and the use of such compounds in consumable products.
• SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES
  申请人：GLYCOM A/S

  公开号：US20160075729A1

  公开（公告）日：2016-03-17

  An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N3 and —OR6 wherein R6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH2)n—NH2 and —(CH2)n—N3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO3H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R2 is selected from H and fucosyl, R3 is selected from H and sialyl, R4 is selected from H and fucosyl, provided that at least one of R3 and R4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.