7-Methoxy-4,4a-dihydrophenoxazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 7-Methoxy-4,4a-dihydrophenoxazin-3-one
• 英文别名: 7-methoxy-4,4a-dihydrophenoxazin-3-one
• 化学式: C₁₃H₁₁NO₃
• 分子量: 229.23
• InChiKey: ZWSIYCMQXVDXRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  47.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• MODIFIED GALACTOOLIGOSACCHARIDES
  申请人：GLYCOM A/S

  公开号：US20150183816A1

  公开（公告）日：2015-07-02

  The invention relates to a method for making modified galactooligosaccharides comprising the step of enzymatic glycosylation, the modified galactooligosaccharides obtainable by the method and consumable products containing them.

  本发明涉及一种制备改性半乳寡糖的方法，包括酶促糖基化步骤，所述方法获得的改性半乳寡糖以及包含它们的可食用产品。
• METHOD FOR GENERATING HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF
  申请人：Dekany Gyula

  公开号：US20140234912A1

  公开（公告）日：2014-08-21

  A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing at least one acceptor from a group of lactose, LNT, LNnT and derivatives thereof, c) providing at least one enzyme comprising a transglycosidase activity and/or a glycosynthase activity, d) preparing a mixture of the at least one donor, at least one acceptor and at least one enzyme provided in steps a), b) and c); and e) incubating the mixture prepared according to step d).

  一种生成人乳寡糖（HMO）或其前体的方法，该方法包括以下步骤：a）提供至少一种来自公式5至10中的化合物组的供体；b）提供至少一种来自乳糖、LNT、LNNT及其衍生物组的受体；c）提供至少一种具有转床苷酶活性和/或糖合成酶活性的酶；d）制备在步骤a）、b）和c）中提供的至少一种供体、至少一种受体和至少一种酶的混合物；e）孵育根据步骤d）制备的混合物。该方法所得到的化合物，以及使用该化合物的组合物和用途也包括在内。
• [EN] SYNTHESIS OF SIALYLATED/FUCOSYLATED OLIGOSACCHARIDES<br/>[FR] SYNTHÈSE D'OLIGOSACCHARIDES SIALYLÉS/FUCOSYLÉS
  申请人：GLYCOM AS

  公开号：WO2014167537A1

  公开（公告）日：2014-10-16

  This invention relates to a chemo-enzymatic synthesis of oligosaccharidesof formula 1 wherein R is selected from -OH, -N3 and -OR6 wherein R6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, -(CH2)n -NH2 and -(CH2)n -N3 wherein integer n is to 10, preferably 2 or 3, R1 is selected from sialyl moiety, -SO3H and -CH(R5)-COOH wherein R5 is selected from H, alkyl and benzyl, R2 is selected from H and fucosyl, R3 is selected from H and sialyl, R4 is selected from H and fucosyl, provided that one but only one of R3 and R4 is H, and A is selected from a bond and a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

  本发明涉及一种化学酶合成公式1的寡糖的方法，其中R从-OH，-N3和-OR6中选择，其中R6从烯丙基选项中选择，烯丙基可以被一个或多个甲基取代，丙炔基可以被一个或多个甲基取代，2-三甲基硅乙基，-(CH2)n -NH2和-( )n -N3，其中整数n为10，优选为2或3，R1从唾液酸基团，-SO3H和-CH(R5)-COOH中选择，其中R5从H，烷基和苄基中选择，R2从H和岩藻糖基中选择，R3从H和唾液酸基中选择，R4从H和岩藻糖基中选择，前提是R3和R4中仅有一个是H，A从一个化学键和双价碳水化合物连接物中选择，具有重要的生物活性和在制药和食品工业中有重要的商业价值。
• [EN] SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES<br/>[FR] SYNTHESE D'OLIGOSACCHARIDES DE LAIT HUMAIN SIALYLES/FUCOSYLES
  申请人：GLYCOM AS

  公开号：WO2014167538A1

  公开（公告）日：2014-10-16

  This invention relates to achemo-enzymatic synthesis of oligosaccharides of formula 1 I wherein R is selected from -OH, -N 3 and -OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, -(CH 2 ) n -NH 2 and -(CH 2 ) n -N 3 wherein integer n is to 10,preferably 2 or 3, R is selected from sialyl moiety, -SO 3 H and -CH(R )-COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at leastone of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

  本发明涉及一种化学酶合成式1I的寡糖的方法，其中R选自-OH，-N3和-OR6，其中R6选自烯丙基（可选地取代一个或多个甲基），丙炔基（可选地取代一个或多个甲基），2-三甲基硅基乙基，-(CH2)n-NH2和-( )n-N3，其中整数n为2至10，优选为2或3，R选自唾液酸基团，-SO3H和-CH(R)-COOH，其中R选自H，烷基和苄基，R2选自H和岩藻糖基，R3选自H和唾液酸基团，R4选自H和岩藻糖基，但至少其中之一为H，A是二价的碳水化合物连接剂，具有重要的生物活性和显著的药物和食品工业商业价值。
• Mutated fucosidase
  申请人：Glycom A/S

  公开号：US10415021B2

  公开（公告）日：2019-09-17

  Mutated fucosidases are provided demonstrating improved properties in terms of thermal stability and transfucosidase synthetic performance compared with a wild type transfucosidase isolated from Bifidobacterium longum subsp. infantis.

  与从长双歧杆菌婴儿亚种中分离出的野生型转褐藻糖苷酶相比，变异的岩藻糖苷酶在热稳定性和转褐藻糖苷酶合成性能方面具有更好的特性。