3-Hydroxy-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-Hydroxy-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid
• 英文别名: 3-hydroxy-9-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)nonanoic acid
• 化学式: C₁₇H₂₆N₂O₃
• 分子量: 306.4
• InChiKey: JDBLAMSPYUHDST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  82.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof
  申请人：SciFluor Life Sciences, Inc.

  公开号：US10301307B2

  公开（公告）日：2019-05-28

  The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating fibrosis, macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及式 I 的含氟化合物以及合成这些化合物的方法。 本发明还涉及含有本发明含氟化合物的药物组合物，以及通过向有需要的受试者施用这些化合物和药物组合物来治疗纤维化、黄斑变性、糖尿病视网膜病变（DR）、黄斑水肿、糖尿病黄斑水肿（DME）和视网膜静脉闭塞（RVO）后黄斑水肿的方法。
• FLUORINATED INTEGRIN ANTAGONISTS
  申请人：Scifluor Life Sciences, Inc

  公开号：EP2953948B1

  公开（公告）日：2017-09-27
• FLUORINATED TETRAHYDRONAPHTHYRIDINYL NONANOIC ACID DERIVATIVES AND USES THEREOF
  申请人：SciFluor Life Sciences, Inc.

  公开号：US20190225609A1

  公开（公告）日：2019-07-25

  The present invention relates to fluorinated compounds of formula I and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing the fluorinated compounds of the invention, and methods of treating fibrosis, macular degeneration, diabetic retinopathy (DR), macular edema, diabetic macular edema (DME), and macular edema following retinal vein occlusion (RVO), by administering these compounds and pharmaceutical compositions to subjects in need thereof.
• US9717729B2
  申请人：——

  公开号：US9717729B2

  公开（公告）日：2017-08-01
• US9790222B2
  申请人：——

  公开号：US9790222B2

  公开（公告）日：2017-10-17