3-(6-Hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentan-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 3-(6-Hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentan-1-one
• 英文别名: 3-(6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentan-1-one
• 化学式: C₂₁H₃₀O
• 分子量: 298.5
• InChiKey: DZCTUQNUQANFRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• BICYCLIC COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：US20140235591A1

  公开（公告）日：2014-08-21

  Disclosed are compounds of Formula (I) and/or a salt thereof; wherein R is —OH or —OP(O)(OH) 2 . Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P 1 , and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

  公开了化合物Formula (I)及/或其盐；其中R为—OH或—OP(O)(OH)2。还公开了使用这些化合物作为G蛋白偶联受体S1P1的选择性激动剂的方法，以及包含这些化合物的药物组合物。这些化合物在治疗、预防或减缓多种治疗领域的疾病或紊乱方面具有用途，如自身免疫疾病和血管疾病。
• US9115054B2
  申请人：——

  公开号：US9115054B2

  公开（公告）日：2015-08-25
• US9359286B2
  申请人：——

  公开号：US9359286B2

  公开（公告）日：2016-06-07
• US9487481B2
  申请人：——

  公开号：US9487481B2

  公开（公告）日：2016-11-08
• [EN] BICYCLIC COMPOUNDS<br/>[FR] COMPOSÉS BICYCLIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014130752A2

  公开（公告）日：2014-08-28

  Disclosed are compounds of Formula (I) and/or a salt thereof; wherein R is -OH or -OP(O)(OH)2. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.