1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;[(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-10,13,16-trimethyl-3-oxo-17-propanoyloxy-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] pentanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;[(8S,10S,11S,13S,14S,16S,17R)-9-fluoro-10,13,16-trimethyl-3-oxo-17-propanoyloxy-17-(2-propanoyloxyacetyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-11-yl] pentanoate
• 化学式: C50H63F2N3O11
• 分子量: 920.0
• InChiKey: JSQNYPJJYPAUGQ-NPAARHFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.14
• 重原子数：
  66
• 可旋转键数：
  16
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  186
• 氢给体数：
  2
• 氢受体数：
  16

文献信息

• FOAM FORMULATIONS
  申请人：OTIC PHARMA LTD

  公开号：US20140234227A1

  公开（公告）日：2014-08-21

  The present invention provides foamable pharmaceutical compositions comprising water-soluble antibiotics and anti-inflammatory steroids and methods of preparing same. Particularly, the present invention relates to oil-free pharmaceutical compositions comprising a quinolone, an anti-inflammatory steroid, a polar co-solvent, and propellant gas, administered to the ear in the form of foam for treating ear disorders.