N-ethyl-N-propan-2-ylpropan-2-amine;2-methyl-N,N-bis(2-methylpropyl)propan-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethyl-N-propan-2-ylpropan-2-amine;2-methyl-N,N-bis(2-methylpropyl)propan-1-amine
• 化学式: C20H46N2
• 分子量: 314.6
• InChiKey: NSBOXSUWUHOBDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.38
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES
  申请人：LAURUS LABS PRIVATE LIMITED

  公开号：US20160016909A1

  公开（公告）日：2016-01-21

  The present invention provides novel intermediates of ivacaftor and process for its preparation. The present invention also provides process for the preparation of ivacaftor and pharmaceutically acceptable salt thereof using novel intermediates.

  本发明提供了ivacaftor的新型中间体及其制备方法。本发明还提供了使用新型中间体制备ivacaftor及其药学上可接受的盐的制备方法。
• US9573902B2
  申请人：——

  公开号：US9573902B2

  公开（公告）日：2017-02-21
• [EN] A PROCESS FOR THE PREPARATION OF IVACAFTOR AND ITS INTERMEDIATES<br/>[FR] PROCÉDÉ DE PRÉPARATION D'IVACAFTOR ET DE SES INTERMÉDIAIRES
  申请人：LAURUS LABS PRIVATE LTD

  公开号：WO2014125506A2

  公开（公告）日：2014-08-21

  The present invention provides novel intermediates of ivacaftor and process for its preparation. The present invention also provides process for the preparation of ivacaftor and pharmaceutically acceptable salt thereof using novel intermediates.