3-(5-fluoro-1H-indol-3-yl)-3H-2-benzofuran-1-one | 1058165-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-(5-fluoro-1H-indol-3-yl)-3H-2-benzofuran-1-one
• CAS: 1058165-00-6
• 化学式: C₁₆H₁₀FNO₂
• 分子量: 267.259
• InChiKey: BMVYWPBVFHSTLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  42.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氟吲哚 、 邻羧基苯甲醛 以 水 为溶剂， 反应 10.0h， 以95%的产率得到3-(5-fluoro-1H-indol-3-yl)-3H-2-benzofuran-1-one
  参考文献：
  名称：

  Highly efficient synthesis of 3-indolyl-substituted phthalides via Friedel–Crafts reactions in water

  摘要：

  An efficient and simple method for the synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reaction of indoles with 2-formylbenzoic acids in pure water has been developed. The reaction affords a wide range of 3-indolyl-substituted phthalides in good to excellent yields. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.06.055

文献信息

• Highly efficient synthesis of 3-indolyl-substituted phthalides via Friedel–Crafts reactions in water
  作者：Hua Lin、Xing-Wen Sun

  DOI：10.1016/j.tetlet.2008.06.055

  日期：2008.9

  An efficient and simple method for the synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reaction of indoles with 2-formylbenzoic acids in pure water has been developed. The reaction affords a wide range of 3-indolyl-substituted phthalides in good to excellent yields. (C) 2008 Elsevier Ltd. All rights reserved.