amino 3-[(6R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]-1-methylcyclopentane-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: amino 3-[(6R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]-1-methylcyclopentane-1-carboxylate
• 化学式: C₂₃H₃₅NO₂
• 分子量: 357.5
• InChiKey: RURBGUFOTAXEBG-OXYBSBDGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• BICYCLIC COMPOUNDS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20160251309A1

  公开（公告）日：2016-09-01

  Disclosed are compounds of Formula (I) and/or a salt thereof; wherein R is —OH or —OP(O)(OH) 2 . Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P 1 , and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

  本发明涉及公式（I）及/或其盐的化合物；其中R为—OH或—OP(O)(OH)2。本发明还涉及使用这些化合物作为选择性G蛋白偶联受体S1P1的激动剂的方法，以及包含这些化合物的药物组合物。这些化合物在多种治疗领域中有用，例如自身免疫疾病和血管疾病，可用于治疗、预防或减缓疾病或障碍的进展。
• US9487481B2
  申请人：——

  公开号：US9487481B2

  公开（公告）日：2016-11-08
• [EN] BICYCLIC COMPOUNDS<br/>[FR] COMPOSÉS BICYCLIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014130752A2

  公开（公告）日：2014-08-28

  Disclosed are compounds of Formula (I) and/or a salt thereof; wherein R is -OH or -OP(O)(OH)2. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.