2,2-Bis(nitrosomethyl)butan-1-ol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2-Bis(nitrosomethyl)butan-1-ol
• 英文别名: 2,2-bis(nitrosomethyl)butan-1-ol
• 化学式: C₆H₁₂N₂O₃
• 分子量: 160.17
• InChiKey: FWALSYPIUCTMFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] FLUORINATED HYPERBRANCHED POLYGLYCEROL POLYMERS AND CORRESPONDING NANOPARTICLES AND ENCAPSULANTS<br/>[FR] POLYMÈRES DE POLYGLYCÉROL HYPERRAMIFIÉ FLUORÉ ET NANOPARTICULES ET AGENTS D'ENCAPSULATION CORRESPONDANTS
  申请人：SOLVAY SPECIALTY POLYMERS IT

  公开号：WO2019243478A1

  公开（公告）日：2019-12-26

  Described herein are fluorinated hyper-branched polyglycerol ("HPG") polymers and corresponding synthesis methods. Also described herein are fluorinated HPG nanoparticles, drug encapsulated fluorinated HPG nanoparticles, and corresponding dispersions. Relative to corresponding non-fluorinated HPG polymers, the fluorinated HPG have desirable 19F nuclear magnetic resonance ("MR") activities for use as 19F magnetic resonance imaging ("MRI") probes. Furthermore, because the fluorinated HPG nanoparticles include, by definition, fluorine, drug loading and encapsulation efficiency is also significantly increased for fluorine containing drugs, relative to corresponding non-fluorinated HPG nanoparticles.

  本文描述了氟化的超支化聚甘油（“HPG”）聚合物及其相应的合成方法。还描述了氟化HPG纳米粒子，药物包封的氟化HPG纳米粒子及其相应的分散液。相对于相应的非氟化HPG聚合物，氟化HPG具有理想的19F核磁共振（“MR”）活性，可用作19F磁共振成像（“MRI”）探针。此外，由于氟化HPG纳米粒子包含氟，因此相对于相应的非氟化HPG纳米粒子，药物的负载和包封效率也显著提高，特别是对含氟药物而言。
• COMPOSITION FOR INHIBITING GENE EXPRESSION AND USES THEREOF
  申请人：Idera Pharmaceuticals, Inc.

  公开号：EP2960333A1

  公开（公告）日：2015-12-30

  The inventors have examined the means for providing more efficacious gene expression blocking compounds. The inventors have discovered new structural features that surprisingly improve the efficacy of gene expression blocking molecules. These features include the presence of multiple 3' ends and a linker at the 5' ends. Surprisingly, these features improve the efficacy of the gene expression blocking compounds in a manner that decreases the compound's biologic instability. Even more surprisingly, this effect has been found to be applicable to both DNA and RNA oligonucleotide-based compounds and to have application in traditional antisense and RNAi technologies.

  本发明者研究了提供更有效基因表达阻断化合物的方法。本发明者发现了新的结构特征，这些特征令人惊讶地提高了基因表达阻断分子的功效。这些特征包括多个 3'末端和 5'末端的连接体。令人惊讶的是，这些特征以降低化合物生物不稳定性的方式提高了基因表达阻断化合物的功效。更令人惊讶的是，这种效果已被发现适用于 DNA 和 RNA 寡核苷酸化合物，并可应用于传统的反义和 RNAi 技术。
• IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE
  申请人：Idera Pharmaceuticals, Inc.

  公开号：EP2982679A1

  公开（公告）日：2016-02-10

  The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

  本发明提供了作为 TLRs 拮抗剂的新型免疫调节寡核苷酸（IRO）及其使用方法。这些IRO具有独特的序列，可抑制或抑制TLR介导的对TLR配体或TLR激动剂的信号传导。这些方法可用于预防和治疗癌症、自身免疫性疾病、气道炎症、炎症性疾病、传染性疾病、皮肤病、过敏、哮喘或由病原体引起的疾病。
• CLEANING COMPOSITIONS CONTAINING A POLYETHERAMINE
  申请人：The Procter & Gamble Company

  公开号：EP3039112B1

  公开（公告）日：2019-03-20
• AQUEOUS DISPERSION, PRODUCTION PROCESS THEREFOR, AND IMAGE FORMATION METHOD
  申请人：FUJIFILM Corporation

  公开号：EP3460014B1

  公开（公告）日：2021-09-08