(13S,17S)-3,17-dimethoxy-13-methyl-6,7,8,9,11,12,14,17-octahydrocyclopenta[a]phenanthrene

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (13S,17S)-3,17-dimethoxy-13-methyl-6,7,8,9,11,12,14,17-octahydrocyclopenta[a]phenanthrene
• 化学式: C₂₀H₂₆O₂
• 分子量: 298.4
• InChiKey: GYZYJAAQFLLHLG-OQPPHWFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for the Production of Estetrol
  申请人：Estetra S.P.R.L.

  公开号：US20140243539A1

  公开（公告）日：2014-08-28

  The present invention relates to a process for the preparation of a compound of formula (I), hydrates or solvates thereof.

  本发明涉及一种制备公式(I)化合物及其水合物或溶剂化物的过程。
• PROCESS FOR THE PREPARATION OF ESTETROL
  申请人：CRYSTAL PHARMA, S.A.U.

  公开号：US20160229885A1

  公开（公告）日：2016-08-11

  The invention relates to a process for obtaining Estetrol or a salt or solvate thereof, the process comprising: a) reacting a compound of formula (IV) or a salt or solvate thereof, wherein R 1 is a hydroxyl protecting group selected from a silyl ether, an ether, an ester, a carbamate and a carbonate, and R 2 is a hydroxyl protecting group selected from an ether, with an oxidizing agent selected from OsO 4 or a source of osmium tetroxide to produce Estetrol or a compound of formula (II) or a salt or solvate thereof wherein R 1 is as defined previously; and b) if a compound of formula (II) is obtained in step a), deprotecting said compound to produce Estetrol.
• US8987484B2
  申请人：——

  公开号：US8987484B2

  公开（公告）日：2015-03-24
• US9988417B2
  申请人：——

  公开号：US9988417B2

  公开（公告）日：2018-06-05