ancistrocongoline A | 455255-21-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: ancistrocongoline A
• 英文别名: (1R,3R)-5-(4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl)-1,2,3-trimethyl-3,4-dihydro-1H-isoquinoline-6,8-diol
• CAS: 455255-21-7
• 化学式: C₂₄H₂₇NO₄
• 分子量: 393.483
• InChiKey: GWJJRDKEDFSIDL-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  73.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 (+)-korupensamine B 在 甲酸 、 sodium formate 作用下， 以 水 为溶剂， 生成 ancistrocongoline A
  参考文献：
  名称：

  Ancistrocongolines A−D, New Naphthylisoquinoline Alkaloids from Ancistrocladus congolensis

  摘要：

  Four new naphthylisoquinoline alkaloids ancistrocongolines A-D (4-7) were isolated from Ancistrocladus congolensis, along with the known compound korupensamine A (8) Structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods Their biological activities against the pathogens of malaria, Leishmaniasis, Chagas disease, and African sleeping sickness were evaluated.

  DOI：

  10.1021/np010622d

文献信息

• Ancistrocongolines A−D, New Naphthylisoquinoline Alkaloids from <i>Ancistrocladus </i><i>c</i><i>ongolensis</i>
  作者：Gerhard Bringmann、Kim Messer、Reto Brun、Virima Mudogo

  DOI：10.1021/np010622d

  日期：2002.8.1

  Four new naphthylisoquinoline alkaloids ancistrocongolines A-D (4-7) were isolated from Ancistrocladus congolensis, along with the known compound korupensamine A (8) Structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods Their biological activities against the pathogens of malaria, Leishmaniasis, Chagas disease, and African sleeping sickness were evaluated.