3-(Methylamino)pentane-1-thiol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(Methylamino)pentane-1-thiol
• 英文别名: 3-(methylamino)pentane-1-thiol
• 化学式: C₆H₁₅NS
• 分子量: 133.26
• InChiKey: MGVHAOIOLUBYBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  13
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• DEGRADABLE THIOL-ENE POLYMERS AND METHODS OF MAKING THEREOF
  申请人：MOSAIC BIOSCIENCES, INC.

  公开号：US20180043030A1

  公开（公告）日：2018-02-15

  Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that a cysteine thiol group, including thiol groups that are separated from the peptide backbone by at least two carbon atoms, for example, the thiol group of a homocysteine residue. Also provided are compositions and biomaterials containing the linked polypeptides, for example, peptide and protein conjugates, and thiol-ene based biocompatible hydrogel polymers, and their uses in the medical field.

  提供了一种使用自由基模拟硫醇-烯化学方法将多肽（包括肽和蛋白质）与其他基团连接的方法，例如，通过引入反应性硫醇基团修饰多肽，并在支持自由基硫醇-烯或硫醇-炔反应的条件下将硫醇基团与含有烯烃或炔烃的试剂反应。反应性硫醇基团对于自由基硫醇-烯反应具有比半胱氨酸硫醇基团更高的活性，包括与肽骨架至少相隔两个碳原子的硫醇基团，例如，同型半胱氨酸残基的硫醇基团。还提供了含有连接的多肽的组合物和生物材料，例如，肽和蛋白质共轭物，以及基于硫醇-烯的生物相容性水凝胶聚合物，以及它们在医学领域中的用途。
• US8822446B2
  申请人：——

  公开号：US8822446B2

  公开（公告）日：2014-09-02
• [EN] BIORENEWABLE EPOXY RESINS DERIVED FROM PHENOLIC ACIDS<br/>[FR] RÉSINES ÉPOXY BIORENOUVELABLES DÉRIVÉES D'ACIDES PHÉNOLIQUES
  申请人：UNIV HOUSTON SYSTEM

  公开号：WO2018035052A1

  公开（公告）日：2018-02-22

  In some aspects, the present disclosure provides epoxy resins from an epoxide containing aromatic compound. The epoxy resin may further comprise one or more curing agents which change the properties of the epoxy resin. Also described herein are methods of preparing epoxy resins using the epoxide containing aromatic compounds and materials prepared with them.