2-Tert-butyl-2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yne

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Tert-butyl-2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yne
• 英文别名: 2-tert-butyl-2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yne
• 化学式: C₁₉H₁₉N
• 分子量: 261.4
• InChiKey: CDYNCNMJPWHUDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• CHEMICAL CROSSLINKERS AND COMPOSITIONS THEREOF
  申请人：Nguyen Mark Quang

  公开号：US20140249319A1

  公开（公告）日：2014-09-04

  Chemical crosslinkers and methods of their synthesis are disclosed.

  化学交联剂及其合成方法已被披露。
• Chemically-Locked Bispecific Antibodies
  申请人：Sorrento Therapeutics, Inc.

  公开号：US20160326266A1

  公开（公告）日：2016-11-10

  There is disclosed a process for forming chemically-locked bispecific or heterodimer antibodies, preferably in the IgG class, in high specificity and with high homogeneity. More specifically, there is disclosed a chemically-locked bispecific IgG class antibody having a linkage region joined together with bio-orthogonal click chemistry.

  公开了一种形成化学锁定的双特异性或异二聚体抗体的过程，优选为IgG类别，具有高特异性和高均一性。更具体地，公开了一种通过生物正交点击化学连接区域连接在一起的化学锁定的双特异性IgG类别抗体。
• RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：The Johns Hopkins University

  公开号：US20210094933A1

  公开（公告）日：2021-04-01

  The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

  本公开提供了受免疫蛋白配体家族FK506和雷帕霉素天然产物启发的大环化合物。生成包含FK506和雷帕霉素结合结构域的Rapafucin大环化合物库，应具有作为治疗疾病新药的潜力。
• CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE
  申请人：NGUYEN MARK QUANG

  公开号：US20140294851A1

  公开（公告）日：2014-10-02

  Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.

  揭示了一种含有易碱性交联剂的易碱性共轭物、其合成和使用方法。
• Universal enzyme responsive linker for assembling ligands on DNA functionalized nanomaterials
  申请人：University of Connecticut

  公开号：US10208072B2

  公开（公告）日：2019-02-19

  Described herein is an enzyme-mediated approach to bioconjugation at nanoparticle (NP) surfaces. This process is enabled by a new synthetic linker compatible with the covalent attachment of alkyne modified substrates, including dyes, peptides and nucleic acids. The methods described herein specifically allow for the linkage of molecules to a DNA-functionalized nanoparticle surface. Enzymatic ligation of molecules to the terminal hydroxyl group of DNA using T4 DNA ligase is achieved through incorporation of a single monophosphate on the approaching substrate. In contrast to previous strategies, the linkers disclosed herein are compatible with alkyne modified molecules of a variety of sizes and charges indicating that the ligase minimally requires the monophosphate and the incoming hydroxyl for conjugation to be successful.

  本文介绍了一种在纳米粒子（NP）表面进行生物连接的酶介导方法。这种新的合成连接剂可与炔类修饰基质（包括染料、肽和核酸）共价连接，从而实现这一过程。本文所述的方法特别允许将分子连接到 DNA 功能化的纳米粒子表面。使用 T4 DNA 连接酶将分子与 DNA 的末端羟基进行酶连接，是通过在接近的底物上加入单磷酸来实现的。与以往的策略不同，本文公开的连接体与各种大小和电荷的炔修饰分子兼容，这表明连接酶只需要单磷酸和进入的羟基就能成功连接。