(6Z,9Z)-N,N,20-trimethylnonacosa-6,9-dien-12-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (6Z,9Z)-N,N,20-trimethylnonacosa-6,9-dien-12-amine
• 化学式: C₃₂H₆₃N
• 分子量: 461.8
• InChiKey: VXMGKICGZVPVEM-LOZNSZTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.7
• 重原子数：
  33
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Methods of using OX40 ligand encoding polynucleotides
  申请人：ModernaTX, Inc.

  公开号：US10383951B2

  公开（公告）日：2019-08-20

  The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules comprising an mRNA encoding an OX40L polypeptide. Also provided is a method for activating T cells or increasing the number of NK cells in a subject in need thereof.

  本公开涉及包含编码 OX40L 多肽的 mRNA 的多核苷酸分子的制备、制造和治疗用组合物和方法。本发明还提供了一种激活 T 细胞或增加 NK 细胞数量的方法。
• US20140255468A1
  申请人：——

  公开号：US20140255468A1

  公开（公告）日：2014-09-11
• METHODS OF USING OX40 LIGAND ENCODING POLYNUCLEOTIDES
  申请人：ModernaTX, Inc.

  公开号：US20190114090A1

  公开（公告）日：2019-04-18

  The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules comprising an mRNA encoding an OX40L polypeptide. Also provided is a method for activating T cells or increasing the number of NK cells in a subject in need thereof.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS
  申请人：ModernaTX, Inc.

  公开号：US20200155706A1

  公开（公告）日：2020-05-21

  The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.