(10S,15R)-4,6-dihydroxy-1,8,11-triazatetracyclo[8.6.0.03,8.011,15]hexadeca-3,6-diene-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡嗪类
• 英文名称: (10S,15R)-4,6-dihydroxy-1,8,11-triazatetracyclo[8.6.0.03,8.011,15]hexadeca-3,6-diene-2,5-dione
• 化学式: C₁₃H₁₅N₃O₄
• 分子量: 277.28
• InChiKey: AFCNSZUFMAEVEH-APPZFPTMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  84.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE-INHIBITING ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：EP2774928A1

  公开（公告）日：2014-09-10

  The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.

  本发明涉及一种具有抗病毒作用的新型化合物，更具体地说，是一种具有艾滋病病毒整合酶抑制活性的吡啶酮衍生物，以及含有该化合物的药物，特别是抗艾滋病病毒药物。本发明的化合物对病毒，特别是艾滋病毒及其耐药菌株具有整合酶抑制活性和/或细胞增殖抑制活性。因此，本发明化合物可用于预防或治疗整合酶参与的各种疾病、病毒感染（如艾滋病）等。
• Polycyclic pyridone derivative having integrase inhibitory activity
  申请人：Shionogi & Co., Ltd.

  公开号：US10011613B2

  公开（公告）日：2018-07-03

  The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.

  本发明涉及一种具有抗病毒作用的新型化合物，更具体地说，是一种具有艾滋病病毒整合酶抑制活性的吡啶酮衍生物，以及含有该化合物的药物，特别是抗艾滋病病毒药物。本发明的化合物对病毒，特别是艾滋病毒及其耐药菌株具有整合酶抑制活性和/或细胞增殖抑制活性。因此，本发明化合物可用于预防或治疗整合酶参与的各种疾病、病毒感染（如艾滋病）等。
• POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：US20170226128A1

  公开（公告）日：2017-08-10

  The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.